Stimulus-cleavable chemistry in the field of controlled drug delivery

Y Xue, H Bai, B Peng, B Fang, J Baell, L Li… - Chemical Society …, 2021 - pubs.rsc.org
Stimulus-cleavable nanoscale drug delivery systems are receiving significant attention
owing to their capability of achieving exquisite control over drug release via the exposure to …

Mechanisms of drug release in nanotherapeutic delivery systems

PT Wong, SK Choi - Chemical reviews, 2015 - ACS Publications
Targeted drug delivery refers to an established therapeutic strategy that develops platforms
and nanoscale devices for selective delivery of small drug molecules and therapeutic genes …

Polymeric conjugates for drug delivery

N Larson, H Ghandehari - Chemistry of Materials, 2012 - ACS Publications
The field of polymer therapeutics has evolved over the past decade and has resulted in the
development of polymer–drug conjugates with a wide variety of architectures and chemical …

A review of drug release mechanisms from nanocarrier systems

C Ding, Z Li - Materials Science and Engineering: C, 2017 - Elsevier
The most common methods used for drug administrations are pills, injections, lotions and
suppositories. The preferred means is oral dosage forms as it is simple, painless and self …

Transepithelial transport and toxicity of PAMAM dendrimers: implications for oral drug delivery

S Sadekar, H Ghandehari - Advanced drug delivery reviews, 2012 - Elsevier
This article summarizes efforts to evaluate poly (amido amine)(PAMAM) dendrimers as
carriers for oral drug delivery. Specifically, the effect of PAMAM generation, surface charge …

Applications of dendrimers in drug delivery agents, diagnosis, therapy, and detection

B Noriega-Luna, LA Godínez… - Journal of …, 2014 - Wiley Online Library
In recent years, the application of dendrimers in biomedicine attracted much attention from
scientists. Dendrimers are interesting for biomedical applications because of their …

Prodrug and nanomedicine approaches for the delivery of the camptothecin analogue SN38

V Bala, S Rao, BJ Boyd, CA Prestidge - Journal of controlled release, 2013 - Elsevier
Abstract SN38 (7-ethyl-10-hydroxy camptothecin) is a prominent and efficacious anticancer
agent. It is poorly soluble in both water and pharmaceutically approved solvents; therefore …

Recent developments in active tumor targeted multifunctional nanoparticles for combination chemotherapy in cancer treatment and imaging

MDK Glasgow, MB Chougule - Journal of biomedical …, 2015 - ingentaconnect.com
Nanotechnology and combination therapy are two major fields that show great promise in
the treatment of cancer. The delivery of drugs via nanoparticles helps to improve drug's …

Association of chemotherapeutic drugs with dendrimer nanocarriers: an assessment of the merits of covalent conjugation compared to noncovalent encapsulation

LM Kaminskas, VM McLeod, CJH Porter… - Molecular …, 2012 - ACS Publications
Cancer is a leading cause of death within developed nations, and part of this morbidity is
due to difficulties associated with its treatment. Currently, anticancer therapy relies heavily …

Disulfide bond-based SN38 prodrug nanoassemblies with high drug loading and reduction-triggered drug release for pancreatic cancer therapy

ZX Zhong, XZ Li, JT Liu, N Qin, HQ Duan… - International Journal of …, 2023 - Taylor & Francis
Purpose Chemotherapy is a significant and effective therapeutic strategy that is frequently
utilized in the treatment of cancer. Small molecular prodrug-based nanoassemblies …