Biomaterials for the delivery of growth factors and other therapeutic agents in tissue engineering approaches to bone regeneration

CJ Kowalczewski, JM Saul - Frontiers in pharmacology, 2018 - frontiersin.org
Bone fracture followed by delayed or non-union typically requires bone graft intervention.
Autologous bone grafts remain the clinical “gold standard”. Recently, synthetic bone grafts …

Culture media for the differentiation of mesenchymal stromal cells

C Vater, P Kasten, M Stiehler - Acta biomaterialia, 2011 - Elsevier
Mesenchymal stromal cells (MSCs) can be isolated from various tissues such as bone
marrow aspirates, fat or umbilical cord blood. These cells have the ability to proliferate in …

Modeling and remodeling of human extraction sockets

L Trombelli, R Farina, A Marzola, L Bozzi… - Journal of clinical …, 2008 - Wiley Online Library
Introduction: The available studies on extraction wound repair in humans are affected by
significant limitations and have failed to evaluate tissue alterations occurring in all …

Bone morphogenetic protein signaling in bone homeostasis

G Sánchez-Duffhues, C Hiepen, P Knaus, P Ten Dijke - Bone, 2015 - Elsevier
Bone morphogenetic proteins (BMPs) are cytokines belonging to the transforming growth
factor-β (TGF-β) superfamily. They play multiple functions during development and tissue …

The role of BMPs in the regulation of osteoclasts resorption and bone remodeling: from experimental models to clinical applications

T Bordukalo-Nikšić, V Kufner, S Vukičević - Frontiers in immunology, 2022 - frontiersin.org
In response to mechanical forces and the aging process, bone in the adult skeleton is
continuously remodeled by a process in which old and damaged bone is removed by bone …

Mesenchymal stem cell ingrowth and differentiation on coralline hydroxyapatite scaffolds

T Mygind, M Stiehler, A Baatrup, H Li, X Zou… - Biomaterials, 2007 - Elsevier
Culture of osteogenic cells on a porous scaffold could offer a new solution to bone grafting
using autologous human mesenchymal stem cells (hMSC) from the patient. We compared …

Mineralization of synthetic polymer scaffolds for bone tissue engineering

JD Kretlow, AG Mikos - Tissue engineering, 2007 - liebertpub.com
It has repeatedly been shown that demineralization improves the ability of bone auto-and
allografts to regenerate natural bone tissue. Conversely, much work in the field of bone …

Biology of bone formation, fracture healing, and distraction osteogenesis

CM Runyan, KS Gabrick - Journal of Craniofacial Surgery, 2017 - journals.lww.com
Distraction osteogenesis is a bone-regenerative process in which an osteotomy is followed
by distraction of the surrounding vascularized bone segments, with formation of new bone …

Temporal and spatial expression of bone morphogenetic proteins in extracorporeal shock wave-promoted healing of segmental defect

FS Wang, KD Yang, YR Kuo, CJ Wang… - Bone, 2003 - Elsevier
Extracorporeal shock wave (ESW) is a noninvasive acoustic wave, which has recently been
demonstrated to promote bone repair. The actual healing mechanism triggered by ESW has …

[HTML][HTML] Molecular and cellular aspects of socket healing in the absence and presence of graft materials and autologous platelet concentrates: A focused review

P de Sousa Gomes, P Daugela… - Journal of oral & …, 2019 - ncbi.nlm.nih.gov
Objectives The present manuscript aims to critically detail the physiologic process of socket
healing, in the absence or presence of grafting materials or platelet concentrates …