Unachieved antiviral strategies with acyclic nucleoside phosphonates: Dedicated to the memory of dr. Salvatore “Sam” Joseph Enna
E De Clercq, G Li, Y Zhang, J Huang, L Tan - Biochemical Pharmacology, 2024 - Elsevier
Many acyclic nucleoside phosphonates such as cidofovir, adefovir dipivoxil, tenofovir
disoproxil fumarate, and tenofovir alafenamide have been marketed for the treatment or …
disoproxil fumarate, and tenofovir alafenamide have been marketed for the treatment or …
Antiviral Activity of Lipophilic Nucleoside Tetraphosphate Compounds
X Jia, D Schols, C Meier - Journal of Medicinal Chemistry, 2024 - ACS Publications
We report on the synthesis and characterization of three types of nucleoside tetraphosphate
derivatives 4–9 acting as potential prodrugs of d4T nucleotides:(i) the δ-phosph (on) ate is …
derivatives 4–9 acting as potential prodrugs of d4T nucleotides:(i) the δ-phosph (on) ate is …
Dehydration as a Preparative Tool in the Crystal Structure Landscape Investigations of Tenofovir
O Kaszubowski, K Ślepokura, KN Truong… - Crystal Growth & …, 2024 - ACS Publications
In this work, we present the use of diffraction-guided dehydration and the complementary
use of various diffraction techniques (including X-ray and electron diffraction) to fully explore …
use of various diffraction techniques (including X-ray and electron diffraction) to fully explore …
Microwave-Accelerated Synthesis of Novel Triphosphate Nucleoside Prodrugs: Expanding the Therapeutic Arsenal of Anticancer Agents
C Tisnerat, S Di Ciano, F Pertusati, M Serpi - Organic Letters, 2024 - ACS Publications
In this study, we report for the first time a microwave-accelerated synthesis of purine and
pyrimidine nucleoside triphosphate prodrugs, whose γ phosphate is masked with an aryloxy …
pyrimidine nucleoside triphosphate prodrugs, whose γ phosphate is masked with an aryloxy …