Preterm birth is an increasing worldwide problem. Prematurity is the second most common
cause of death in children under 5 years of age. It is associated with a higher risk of several …

Epidemiological surveys indicate that nutrition in infancy is implicated in the long-term
tendency to obesity and that a longer duration of breastfeeding is associated with a …

The metabolic actions of the ghrelin gene‐derived peptide obestatin are still unclear. We
investigated obestatin effects in vitro, on adipocyte function, and in vivo, on insulin …

Several studies have shown that ghrelin administration promotes wakefulness in rodents,
while in human males it induces sleep but has no effect in women. Ghrelin also plays an …

Obestatin is a 23‐amino acid C‐terminally amidated gastrointestinal peptide derived from
preproghrelin and which forms an α helix. Although obestatin has a short biological half‐life …

Introduction: Pigment epithelium-derived factor (PEDF) was discovered as a neurotrophic
factor secreted by retinal pigment epithelial cells. A decade later, it re-emerged as a …

Aromatase converts androgens into estrogens and its expression within adipose stromal
cells (ASCs) is believed to be the major driver of estrogen-dependent cancers in older …

Obestatin was identified in 2005 by Zhang and colleagues as a ghrelin-associated peptide,
derived from posttranslational processing of the prepro-ghrelin gene. Initially, obestatin was …

Ghrelin and motilin are released from gastrointestinal endocrine cells during hunger, to act
through G protein-coupled receptors that have closely related amino acid sequences. The …

Background Ghrelin and obestatin are two gastric hormones encoded by the same
preproghrelin gene that convey information concerning nutritional status to the central …