The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …

Type I and type II interferons (IFN) are central to both combating virus infection and
modulating the antiviral immune response. Indeed, an absence of either the receptor for type …

Longitudinal analyses of the innate immune system, including the earliest time points, are
essential to understand the immunopathogenesis and clinical course of coronavirus disease …

Abstract Kinases of the Jak ('Janus kinase') family and transcription factors (TFs) of the STAT
('signal transducer and activator of transcription') family constitute a rapid membrane-to …

Type I interferons (IFNs) have diverse effects on innate and adaptive immune cells during
infection with viruses, bacteria, parasites and fungi, directly and/or indirectly through the …

More than two decades ago, experiments on the antiviral mechanisms of IFNs led to the
discovery of JAKs and their downstream effectors, the STAT proteins. This pathway has …

Type I interferons (IFNs) are pleiotropic cytokines well recognized for their role in the
induction of a potent antiviral gene program essential for host defense against viruses. They …

Understanding how signals are integrated to control natural killer (NK) cell responsiveness
in the absence of antigen-specific receptors has been a challenge, but recent work has …

Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections account for 57% of
cases of liver cirrhosis and 78% of cases of primary liver cancer worldwide and cause a …

Natural Killer (NK) cells are cytotoxic lymphocytes of the innate immune system and play a
critical role in anti-viral and anti-tumor responses. NK cells develop in the bone marrow from …