Mechanisms of SNARE proteins in membrane fusion

R Jahn, DC Cafiso, LK Tamm - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) are a
family of small conserved eukaryotic proteins that mediate membrane fusion between …

Mechanics of membrane fusion

LV Chernomordik, MM Kozlov - Nature structural & molecular biology, 2008 - nature.com
Diverse membrane fusion reactions in biology involve close contact between two lipid
bilayers, followed by the local distortion of the individual bilayers and reformation into a …

Mechanisms of membrane fusion: disparate players and common principles

S Martens, HT McMahon - Nature reviews Molecular cell biology, 2008 - nature.com
Membrane fusion can occur between cells, between different intracellular compartments,
between intracellular compartments and the plasma membrane and between lipid-bound …

How does synaptotagmin trigger neurotransmitter release?

ER Chapman - Annu. Rev. Biochem., 2008 - annualreviews.org
Neurotransmitter release at synapses involves a highly specialized form of membrane fusion
that is triggered by Ca2+ ions and is optimized for speed. These observations were …

Helical extension of the neuronal SNARE complex into the membrane

A Stein, G Weber, MC Wahl, R Jahn - Nature, 2009 - nature.com
Neurotransmission relies on synaptic vesicles fusing with the membrane of nerve cells to
release their neurotransmitter content into the synaptic cleft, a process requiring the …

[HTML][HTML] Selective activation of cognate SNAREpins by Sec1/Munc18 proteins

J Shen, DC Tareste, F Paumet, JE Rothman, TJ Melia - Cell, 2007 - cell.com
Summary Sec1/Munc18 (SM) proteins are required for every step of intracellular membrane
fusion, but their molecular mechanism of action has been unclear. In this work, we …

The dynamic control of kiss-and-run and vesicular reuse probed with single nanoparticles

Q Zhang, Y Li, RW Tsien - Science, 2009 - science.org
Vesicular secretion of neurotransmitter is essential for neuronal communication. Kiss-and-
run is a mode of membrane fusion and retrieval without the full collapse of the vesicle into …

Localized, highly efficient secretion of signaling proteins by migrasomes

H Jiao, X Li, Y Li, Y Guo, X Hu, T Sho, Y Luo, J Wang… - Cell research, 2024 - nature.com
Migrasomes, enriched with signaling molecules such as chemokines, cytokines and
angiogenic factors, play a pivotal role in the spatially defined delivery of these molecules …

From the stochasticity of molecular processes to the variability of synaptic transmission

C Ribrault, K Sekimoto, A Triller - Nature Reviews Neuroscience, 2011 - nature.com
The variability of the postsynaptic response following a single action potential arises from
two sources: the neurotransmitter release is probabilistic, and the postsynaptic response to …

Energetics and dynamics of SNAREpin folding across lipid bilayers

F Li, F Pincet, E Perez, WS Eng, TJ Melia… - Nature structural & …, 2007 - nature.com
Membrane fusion occurs when SNAREpins fold up between lipid bilayers. How much
energy is generated during SNAREpin folding and how this energy is coupled to the fusion …