Molecular and cellular insights into the development of uterine fibroids

A Machado-Lopez, C Simón, A Mas - International journal of molecular …, 2021 - mdpi.com
Uterine leiomyomas represent the most common benign gynecologic tumor. These hormone-
dependent smooth-muscle formations occur with an estimated prevalence of~ 70% among …

Immunosuppressive tumor microenvironment and uterine fibroids: Role in collagen synthesis

EE Saad, R Michel, MA Borahay - Cytokine & growth factor reviews, 2024 - Elsevier
Uterine fibroids (UF), also called uterine leiomyoma, is one of the most prevalent uterine
tumors. UF represents a serious women's health global problem with a significant physical …

Remotely temporal scheduled macrophage phenotypic transition enables optimized immunomodulatory bone regeneration

D Huang, K Xu, X Huang, N Lin, Y Ye, S Lin, J Zhang… - Small, 2022 - Wiley Online Library
Precise timing of macrophage polarization plays a pivotal role in immunomodulation of
tissue regeneration, yet most studies mainly focus on M2 macrophages for their anti …

Comprehensive review of uterine leiomyosarcoma: pathogenesis, diagnosis, prognosis, and targeted therapy

Q Yang, OS Madueke-Laveaux, H Cun, M Wlodarczyk… - Cells, 2024 - mdpi.com
Uterine leiomyosarcoma (uLMS) is the most common subtype of uterine sarcomas. They
have a poor prognosis with high rates of recurrence and metastasis. The five-year survival …

Update on the role and regulatory mechanism of extracellular matrix in the pathogenesis of uterine fibroids

Q Yang, A Al-Hendy - International Journal of Molecular Sciences, 2023 - mdpi.com
Uterine fibroids (UFs), also known as leiomyomas, are benign tumors of the myometrium
affecting over 70% of women worldwide, particularly women of color. Although benign, UFs …

Targeting fibrotic signaling pathways by EGCG as a therapeutic strategy for uterine fibroids

MS Islam, M Parish, JT Brennan, BL Winer… - Scientific reports, 2023 - nature.com
Fibrosis is characterized by excessive accumulation of extracellular matrix, which is a key
feature of uterine fibroids. Our prior research supports the tenet that inhibition of fibrotic …

The influence of race/ethnicity on the transcriptomic landscape of uterine fibroids

TD Chuang, N Ton, S Rysling, D Quintanilla… - International journal of …, 2023 - mdpi.com
The objective of this study was to determine if the aberrant expression of select genes could
form the basis for the racial disparity in fibroid characteristics. The next-generation RNA …

[HTML][HTML] Progesterone signaling in uterine leiomyoma biology: Implications for potential targeted therapy

W Szucio, P Bernaczyk, D Ponikwicka-Tyszko… - Advances in Medical …, 2024 - Elsevier
Uterine leiomyomas (ULs) are the most common benign smooth muscle cell steroid-
dependent tumors that occur in women of reproductive age. Progesterone (P4) is a major …

Importance of fibrosis in the pathogenesis of uterine leiomyoma and the promising anti-fibrotic effects of dipeptidyl peptidase-4 and fibroblast activation protein …

AS Bhat, NA Singh, E Rymbai, S Birendra… - Reproductive …, 2023 - Springer
Uterine fibroid or leiomyoma is the most common benign uterus tumor. The tumor is primarily
composed of smooth muscle (fibroid) cells, myofibroblast, and a significant amount of …

New insights on the potential effect of progesterone in Covid‐19: Anti‐inflammatory and immunosuppressive effects

HM Al‐Kuraishy, TJ Al‐Maiahy… - Immunity …, 2023 - Wiley Online Library
Abstract Background: Coronavirus disease 2019 (COVID‐19) is a pandemic disease caused
by severe acute respiratory syndrome CoV type 2 (SARS‐CoV‐2). COVID‐19 is higher in …