Abacavir hypersensitivity syndrome (AHS) is a potentially life-threatening illness occurring in
4–8% of those initiating the drug. Early studies identified a strong association between the …

Background Hypersensitivity reaction to abacavir is strongly associated with the presence of
the HLA-B* 5701 allele. This study was designed to establish the effectiveness of …

Systemic drug-induced hypersensitivity reactions (HSRs) have been reported for a variety of
drugs, and are thought to have a combined immunological, genetic and metabolic basis …

Aim: To determine diagnostic accuracy of HLA-B* 57: 01 testing for prediction of abacavir-
induced hypersensitivity and to quantify the clinical benefit of pretreatment screening …

Differences in HIV acquisition and progression as well as antiretroviral efficacy and toxicity
will continue to provide the basis for research to define the genetic basis of such diversity …

Abacavir is a potent nucleoside analog reverse transcriptase inhibitor approved for the
treatment of HIV infection. Approximately 5–8% of Caucasian patients receiving abacavir …

There are several clinical guidelines for the diagnosis and treatment of HIV/AIDS which are
used extensively in other countries. However, the implementation of such guidelines is not …

The concept of personalizing antiretroviral therapy is not novel, since the complexity of the
HIV patient and their therapy has always demanded consideration of the patient's …

This study was designed to establish the prevalence of HLA-B* 5701 at HIV-1 infected
individuals in Brazil. A total of 517 consecutive individuals were followed in this study from …

The best choosing of antiretroviral therapy for an individual patient is one that physicians
have always tried to practice, making use of whatever knowledge or tools are available to …