Primary immunodeficiencies (PID) are disorders that for the most part result from mutations
in genes involved in immune host defense and immunoregulation. These conditions are …

Much has been learned about how cells enter lymphoid tissues. But how do they leave?
Sphingosine-1-phosphate (S1P) has emerged over the past decade as a central mediator of …

Background Recurrent sinopulmonary and cutaneous viral infections with elevated serum
levels of IgE are features of some variants of combined immunodeficiency. The genetic …

In the last years, advances in molecular genetics and immunology have resulted in the
identification of a growing number of genes causing primary immunodeficiencies (PIDs) in …

The shuttling of leukocytes between the bloodstream and interstitial tissues involves different
locomotion strategies that are governed by locally presented soluble and cell-bound signals …

The American Academy of Allergy, Asthma & Immunology (AAAAI) and the American
College of Allergy, Asthma & Immunology (ACAAI) have jointly accepted responsibility for …

BACKGROUND: The genetic etiologies of the hyper-IgE syndromes are diverse.
Approximately 60% to 70% of patients with hyper-IgE syndrome have dominant mutations in …

Ubiquitously expressed β-actin and γ-actin isoforms play critical roles in most cellular
processes; however, their unique contributions are not well understood. We generated …

Can genetic and clinical findings made in a single patient be considered sufficient to
establish a causal relationship between genotype and phenotype? We report that up to 49 of …

Severe combined immunodeficiencies (SCIDs) comprise a group of rare, monogenic
diseases that are characterized by an early onset and a profound block in the development …