Precision oncology applies genomic and other molecular analyses of tumor biopsies to
improve the diagnosis and treatment of cancers. In addition to identifying therapeutic …

The small GTPase Rac1 has been implicated in a variety of dynamic cell biological
processes, including cell proliferation, cell survival, cell-cell contacts, epithelial …

Mutational signature analysis is commonly performed in cancer genomic studies. Here, we
present SigProfilerExtractor, an automated tool for de novo extraction of mutational …

Tumor suppressor genes (TSGs) are a major type of gatekeeper genes in the cell growth. A
knowledgebase with the systematic collection and curation of TSGs in multiple cancer types …

Esophageal squamous cell carcinoma (ESCC) is a poor-prognosis cancer type with limited
understanding of its molecular etiology. Using 508 ESCC genomes, we identified five novel …

The underlining mechanisms of dietary cholesterol and nonalcoholic steatohepatitis (NASH)
in contributing to hepatocellular carcinoma (HCC) remain undefined. Here we demonstrated …

Abstrict LINC00941 is a novel lncRNA that has been found to exhibit protumorigenic and
prometastatic behaviors during tumorigenesis. However, its role in metastatic CRC remains …

Background & Aims A long duration of inflammatory bowel disease (IBD) increases the risk
for colorectal cancer. Mutation analysis of limited numbers of genes has indicated that …

Purpose: Understanding the mechanism of radioresistance could help develop strategies to
improve therapeutic response of patients with PDAC. The SMAD4 gene is frequently …

Small cell lung cancer (SCLC) is an aggressive disease with poor survival. A few
sequencing studies performed on limited number of samples have revealed potential …