Reversible interactions of glycoconjugates on leukocytes with P-and E-selectin on
endothelial cells mediate tethering and rolling of leukocytes in inflamed vascular beds, the …

Rolling adhesion on vascular surfaces is the first step in recruiting circulating leukocytes,
hematopoietic progenitors, or platelets to specific organs or to sites of infection or injury …

Bonds between adhesion molecules are often mechanically stressed. A striking example is
the tensile force applied to selectin–ligand bonds, which mediate the tethering and rolling of …

Interactions of selectins with cell-surface glycoconjugates mediate tethering and rolling
adhesion of leukocytes and platelets on vascular surfaces. Recent studies have helped …

Arterial blood flow enhances glycoprotein Ibα (GPIbα) binding to vWF, which initiates platelet
adhesion to injured vessels. Mutations in the vWF A1 domain that cause type 2B von …

Many small proteins seem to fold by a simple process explicable by conventional chemical
kinetics and transition-state theory. This assumes an instant equilibrium between reactants …

In inflamed venules, neutrophils rolling on E-selectin induce integrin αLβ2-dependent slow
rolling on intercellular adhesion molecule-1 by activating Src family kinases (SFKs), DAP12 …

Integrins comprise a large family of cell-cell and cell-matrix adhesion receptors that rapidly
modulate their adhesiveness. The arrest of leukocyte integrins on target vascular beds …

Selectin-ligand interactions mediate the tethering and rolling of circulating leukocytes on
vascular surfaces during inflammation and immune surveillance. To support rolling, these …

Flow-enhanced cell adhesion is an unexplained phenomenon that might result from a
transport-dependent increase in on-rates or a force-dependent decrease in off-rates of …