An abundant metal in the human body, iron is essential for key biological pathways
including oxygen transport, DNA metabolism, and mitochondrial function. Most iron is bound …

Multidrug resistance (MDR) is the phenomenon in which cancer cells simultaneously
develop resistance to a broad spectrum of structurally and mechanistically unrelated drugs …

Cancer cells frequently display intrinsic or acquired resistance to chemically diverse
anticancer drugs, limiting therapeutic success. Among the main mechanisms of this …

ATP-binding cassette (ABC) transporters constitute one of the largest and most ancient
protein superfamilies found in all living organisms. They function as molecular machines by …

ABC transporters are essential for cellular physiology. Humans have 48 ABC genes
organized into seven distinct families. Of these genes, 44 (in five distinct families) encode for …

Multiple drug resistance (MDR), referring to the resistance of cancer cells to a broad
spectrum of structurally and mechanistically unrelated drugs across membranes, severely …

Members of the ATP‐binding cassette (ABC) transporter superfamily translocate a broad
spectrum of chemically diverse substrates. While their eponymous ATP‐binding cassette in …

ABCB1 detoxifies cells by exporting diverse xenobiotic compounds, thereby limiting drug
disposition and contributing to multidrug resistance in cancer cells. Multiple small-molecule …

ABCG2 is an ABC transporter that extrudes a variety of compounds from cells, and presents
an obstacle in treating chemotherapy-resistant cancers. Despite recent structural insights, no …

Abscisic acid (ABA) is a phytohormone essential to the regulation of numerous aspects of
plant growth and development. The cellular level of ABA is critical to its signalling and is …