SARS-CoV-2 antiviral therapy

K Tao, PL Tzou, J Nouhin, H Bonilla… - Clinical microbiology …, 2021 - Am Soc Microbiol
The development of effective antiviral therapy for COVID-19 is critical for those awaiting
vaccination, as well as for those who do not respond robustly to vaccination. This review …

Drug repurposing for COVID-19: A review and a novel strategy to identify new targets and potential drug candidates

L Rodrigues, R Bento Cunha, T Vassilevskaia… - Molecules, 2022 - mdpi.com
In December 2019, the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2), the causative agent of coronavirus disease 2019 (COVID-19) was first identified in the …

TMPRSS2 expression dictates the entry route used by SARS‐CoV‐2 to infect host cells

J Koch, ZM Uckeley, P Doldan, M Stanifer… - The EMBO …, 2021 - embopress.org
SARS‐CoV‐2 is a newly emerged coronavirus that caused the global COVID‐19 outbreak in
early 2020. COVID‐19 is primarily associated with lung injury, but many other clinical …

Reduced interferon antagonism but similar drug sensitivity in Omicron variant compared to Delta variant of SARS-CoV-2 isolates

D Bojkova, M Widera, S Ciesek, MN Wass, M Michaelis… - Cell research, 2022 - nature.com
Dear Editor, Omicron (B. 1.1. 529), is a heavily mutated and highly contagious SARS-CoV-2
variant, which is currently causing large outbreaks in many countries. Protection provided by …

The transmembrane protease TMPRSS2 as a therapeutic target for COVID-19 treatment

L Wettstein, F Kirchhoff, J Münch - International Journal of Molecular …, 2022 - mdpi.com
TMPRSS2 is a type II transmembrane protease with broad expression in epithelial cells of
the respiratory and gastrointestinal tract, the prostate, and other organs. Although the …

[HTML][HTML] Protein structure-based in-silico approaches to drug discovery: Guide to COVID-19 therapeutics

Y Gupta, OV Savytskyi, M Coban, A Venugopal… - Molecular Aspects of …, 2023 - Elsevier
With more than 5 million fatalities and close to 300 million reported cases, COVID-19 is the
first documented pandemic due to a coronavirus that continues to be a major health …

In vitro lung models and their application to study SARS-CoV-2 pathogenesis and disease

N Heinen, M Kloehn, E Steinmann, S Pfaender - Viruses, 2021 - mdpi.com
SARS-CoV-2 has spread across the globe with an astonishing velocity and lethality that has
put scientist and pharmaceutical companies worldwide on the spot to develop novel …

Generation of a sleeping beauty transposon-based cellular system for rapid and sensitive screening for compounds and cellular factors limiting SARS-CoV-2 …

M Widera, A Wilhelm, T Toptan, JM Raffel… - Frontiers in …, 2021 - frontiersin.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent
of the acute respiratory disease COVID-19, which has become a global concern due to its …

Identification of a dual acting SARS-CoV-2 proteases inhibitor through in silico design and step-by-step biological characterization

V Di Sarno, G Lauro, S Musella, T Ciaglia… - European Journal of …, 2021 - Elsevier
COVID-19 pandemic, starting from the latest 2019, and caused by SARS-CoV-2 pathogen,
led to the hardest health-socio-economic disaster in the last century. Despite the …

Aprotinin treatment against SARS‐CoV‐2: a randomized phase III study to evaluate the safety and efficacy of a pan‐protease inhibitor for moderate COVID‐19

FJ Redondo‐Calvo, JF Padín… - European Journal of …, 2022 - Wiley Online Library
Background SARS‐CoV‐2 virus requires host proteases to cleave its spike protein to bind to
its ACE2 target through a two‐step furin‐mediated entry mechanism. Aprotinin is a broad …