The perturbation of DNA replication, a phenomena termed “replication stress”, is a driving
force of genome instability and a hallmark of cancer cells. Among the DNA repair …

Proliferating cells regularly experience replication stress caused by spontaneous DNA
damage that results from endogenous reactive oxygen species (ROS), DNA sequences that …

Replication fork reversal is an important mechanism to protect the stability of stalled forks
and thereby preserve genomic integrity. While multiple enzymes have been identified that …

Transcription–replication conflicts occur when the two critical cellular machineries
responsible for gene expression and genome duplication collide with each other on the …

The 5-hydroxymethylcytosine binding, embryonic stem-cell-specific (HMCES) protein forms
a covalent DNA-protein cross-link (DPC) with abasic (AP) sites in single-stranded DNA, and …

Replicative DNA polymerases are blocked by nearly all types of DNA damage. The resulting
DNA replication stress threatens genome stability. DNA replication stress is also caused by …

DNA replication is remarkably accurate with estimates of only a handful of mutations per
human genome per cell division cycle. Replication stress caused by DNA lesions …

Dealing with DNA lesions during genome replication is particularly challenging because
damaged replication templates interfere with the progression of the replicative DNA …

Cells respond to DNA damage by activating signaling and DNA repair systems, described
as the DNA damage response (DDR). Clarifying DDR pathways and their dysregulation in …

The maintenance of telomeres, which are specialized stretches of DNA found at the ends of
linear chromosomes, is a crucial step for the immortalization of cancer cells. Approximately …