Glaucoma a debilitating disease, is globally the second most common kind of permanent
blindness. Primary open-angle glaucoma (POAG) is its most prevalent form and is often …

Myocilin is highly expressed in the trabecular meshwork (TM), which plays an important role
in the regulation of intraocular pressure (IOP). Myocilin abnormalities may cause dysfunction …

Glucose regulated protein 94 (Grp94) is the endoplasmic reticulum resident of the heat
shock protein 90 kDa (Hsp90) family of molecular chaperones. Grp94 associates with many …

Olfactomedin (OLF) domain-containing proteins play roles in fundamental cellular processes
and have been implicated in disorders ranging from glaucoma, cancers and inflammatory …

Mutations in the gene MYOC account for approximately 5% of cases of primary open angle
glaucoma (POAG). MYOC encodes for the protein myocilin, a multimeric secreted …

Glaucoma, a heterogeneous ocular disorder affecting∼ 60 million people worldwide, is
characterized by painless neurodegeneration of retinal ganglion cells (RGCs), resulting in …

Conspectus Numerous human disorders arise due to the inability of a particular protein to
adopt its correct three-dimensional structure in the context of the cell, leading to aggregation …

Studies of folded-to-misfolded transitions using model protein systems reveal a range of
unfolding needed for exposure of amyloid-prone regions for subsequent fibrillization. Here …

Gain-of-function mutations in the olfactomedin domain of the MYOC gene facilitate the toxic
accumulation of amyloid-containing myocilin aggregates, hastening the onset of the …

Rare variants of the olfactomedin domain of myocilin are considered causative for inherited,
early‐onset open‐angle glaucoma, with a misfolding toxic gain‐of‐function pathogenic …