Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
AMPA receptor structure and auxiliary subunits
A Kamalova, T Nakagawa - The Journal of physiology, 2021 - Wiley Online Library
Fast excitatory synaptic transmission in the mammalian brain is largely mediated by AMPA‐
type ionotropic glutamate receptors (AMPARs), which are activated by the neurotransmitter …
type ionotropic glutamate receptors (AMPARs), which are activated by the neurotransmitter …
[HTML][HTML] Modulation of GluA2–γ5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2
SP Gangwar, LY Yen, MV Yelshanskaya… - Nature Structural & …, 2023 - nature.com
Synaptic complexes of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)
receptors (AMPARs) with auxiliary subunits mediate most excitatory neurotransmission and …
receptors (AMPARs) with auxiliary subunits mediate most excitatory neurotransmission and …
[HTML][HTML] GSG1L-containing AMPA receptor complexes are defined by their spatiotemporal expression, native interactome and allosteric sites
AM Perozzo, J Schwenk, A Kamalova… - Nature …, 2023 - nature.com
Transmembrane AMPA receptor regulatory proteins (TARPs) and germ cell-specific gene 1-
like protein (GSG1L) are claudin-type AMPA receptor (AMPAR) auxiliary subunits that …
like protein (GSG1L) are claudin-type AMPA receptor (AMPAR) auxiliary subunits that …
[HTML][HTML] Structure and desensitization of AMPA receptor complexes with type II TARP γ5 and GSG1L
AMPA receptors (AMPARs) mediate the majority of excitatory neurotransmission. Their
surface expression, trafficking, gating, and pharmacology are regulated by auxiliary …
surface expression, trafficking, gating, and pharmacology are regulated by auxiliary …
[HTML][HTML] Parkinson's disease, epilepsy, and amyotrophic lateral sclerosis—emerging role of AMPA and kainate subtypes of ionotropic glutamate receptors
MN Vukolova, LY Yen, MI Khmyz… - Frontiers in Cell and …, 2023 - frontiersin.org
Ionotropic glutamate receptors (iGluRs) mediate the majority of excitatory neurotransmission
and are implicated in various neurological disorders. In this review, we discuss the role of …
and are implicated in various neurological disorders. In this review, we discuss the role of …
[HTML][HTML] Clinical and functional consequences of GRIA variants in patients with neurological diseases
W XiangWei, RE Perszyk, N Liu, Y Xu… - Cellular and Molecular …, 2023 - Springer
AMPA receptors are members of the glutamate receptor family and mediate a fast
component of excitatory synaptic transmission at virtually all central synapses. Thus, their …
component of excitatory synaptic transmission at virtually all central synapses. Thus, their …
Hodgkin–Huxley–Katz Prize Lecture: genetic and pharmacological control of glutamate receptor channel through a highly conserved gating motif
RE Perszyk, SJ Myers, H Yuan, AJ Gibb… - The Journal of …, 2020 - Wiley Online Library
Glutamate receptors are essential ligand‐gated ion channels in the central nervous system
that mediate excitatory synaptic transmission in response to the release of glutamate from …
that mediate excitatory synaptic transmission in response to the release of glutamate from …
Building of AMPA‐type glutamate receptors in the endoplasmic reticulum and its implication for excitatory neurotransmission
J Schwenk, B Fakler - The Journal of Physiology, 2021 - Wiley Online Library
AMPA‐type glutamate receptors (AMPARs), the key elements of fast excitatory
neurotransmission in the brain, are receptor ion channels whose core is assembled from …
neurotransmission in the brain, are receptor ion channels whose core is assembled from …
Alternative splicing of the flip/flop cassette and TARP auxiliary subunits engage in a privileged relationship that fine-tunes AMPA receptor gating
AM Perozzo, PMGE Brown, D Bowie - Journal of Neuroscience, 2023 - Soc Neuroscience
Alternative splicing of AMPA-type glutamate receptors (AMPARs) and allosteric modulation
by auxiliary subunits, such as transmembrane AMPAR regulatory proteins (TARPs), are two …
by auxiliary subunits, such as transmembrane AMPAR regulatory proteins (TARPs), are two …