Clinical application of mesenchymal stem cell in regenerative medicine: a narrative review
R Margiana, A Markov, AO Zekiy, MU Hamza… - Stem Cell Research & …, 2022 - Springer
The multipotency property of mesenchymal stem cells (MSCs) has attained worldwide
consideration because of their immense potential for immunomodulation and their …
consideration because of their immense potential for immunomodulation and their …
The E-cadherin and N-cadherin switch in epithelial-to-mesenchymal transition: signaling, therapeutic implications, and challenges
Epithelial-to-Mesenchymal Transition (EMT) has been shown to be crucial in tumorigenesis
where the EMT program enhances metastasis, chemoresistance and tumor stemness. Due …
where the EMT program enhances metastasis, chemoresistance and tumor stemness. Due …
Injectable and biodegradable piezoelectric hydrogel for osteoarthritis treatment
T Vinikoor, GK Dzidotor, TT Le, Y Liu, HM Kan… - Nature …, 2023 - nature.com
Osteoarthritis affects millions of people worldwide but current treatments using analgesics or
anti-inflammatory drugs only alleviate symptoms of this disease. Here, we present an …
anti-inflammatory drugs only alleviate symptoms of this disease. Here, we present an …
Biological functions of mesenchymal stem cells and clinical implications
Mesenchymal stem cells (MSCs) are isolated from multiple biological tissues—adult bone
marrow and adipose tissues and neonatal tissues such as umbilical cord and placenta. In …
marrow and adipose tissues and neonatal tissues such as umbilical cord and placenta. In …
Chondrocyte dedifferentiation and osteoarthritis (OA)
E Charlier, C Deroyer, F Ciregia, O Malaise… - Biochemical …, 2019 - Elsevier
Osteoarthritis (OA) is a degenerative joint disease characterized by progressive cartilage
degradation but also synovial membrane inflammation, osteophyte formation and …
degradation but also synovial membrane inflammation, osteophyte formation and …
TGFβ/BMP signaling pathway in cartilage homeostasis
NGM Thielen, PM van der Kraan, APM van Caam - Cells, 2019 - mdpi.com
Cartilage homeostasis is governed by articular chondrocytes via their ability to modulate
extracellular matrix production and degradation. In turn, chondrocyte activity is regulated by …
extracellular matrix production and degradation. In turn, chondrocyte activity is regulated by …
[HTML][HTML] Mesenchymal stromal/stem cell-derived extracellular vesicles promote human cartilage regeneration in vitro
Osteoarthritis (OA) is a rheumatic disease leading to chronic pain and disability with no
effective treatment available. Recently, allogeneic human mesenchymal stromal/stem cells …
effective treatment available. Recently, allogeneic human mesenchymal stromal/stem cells …
Polymeric materials for bone and cartilage repair
The past decade has seen the rapid development of new strategies for the design of
biodegradable macromolecular compounds, with properly suited architecture and tailored …
biodegradable macromolecular compounds, with properly suited architecture and tailored …
TGF-β family signaling in mesenchymal differentiation
I Grafe, S Alexander, JR Peterson… - Cold Spring …, 2018 - cshperspectives.cshlp.org
Mesenchymal stem cells (MSCs) can differentiate into several lineages during development
and also contribute to tissue homeostasis and regeneration, although the requirements for …
and also contribute to tissue homeostasis and regeneration, although the requirements for …
Three-dimensional aggregates of mesenchymal stem cells: cellular mechanisms, biological properties, and applications
Mesenchymal stem cells (MSCs) are primary candidates in cell therapy and tissue
engineering and are being tested in clinical trials for a wide range of diseases. Originally …
engineering and are being tested in clinical trials for a wide range of diseases. Originally …