Clinical application of mesenchymal stem cell in regenerative medicine: a narrative review

R Margiana, A Markov, AO Zekiy, MU Hamza… - Stem Cell Research & …, 2022 - Springer
The multipotency property of mesenchymal stem cells (MSCs) has attained worldwide
consideration because of their immense potential for immunomodulation and their …

The E-cadherin and N-cadherin switch in epithelial-to-mesenchymal transition: signaling, therapeutic implications, and challenges

CY Loh, JY Chai, TF Tang, WF Wong, G Sethi… - Cells, 2019 - mdpi.com
Epithelial-to-Mesenchymal Transition (EMT) has been shown to be crucial in tumorigenesis
where the EMT program enhances metastasis, chemoresistance and tumor stemness. Due …

Injectable and biodegradable piezoelectric hydrogel for osteoarthritis treatment

T Vinikoor, GK Dzidotor, TT Le, Y Liu, HM Kan… - Nature …, 2023 - nature.com
Osteoarthritis affects millions of people worldwide but current treatments using analgesics or
anti-inflammatory drugs only alleviate symptoms of this disease. Here, we present an …

Biological functions of mesenchymal stem cells and clinical implications

A Naji, M Eitoku, B Favier, F Deschaseaux… - Cellular and Molecular …, 2019 - Springer
Mesenchymal stem cells (MSCs) are isolated from multiple biological tissues—adult bone
marrow and adipose tissues and neonatal tissues such as umbilical cord and placenta. In …

Chondrocyte dedifferentiation and osteoarthritis (OA)

E Charlier, C Deroyer, F Ciregia, O Malaise… - Biochemical …, 2019 - Elsevier
Osteoarthritis (OA) is a degenerative joint disease characterized by progressive cartilage
degradation but also synovial membrane inflammation, osteophyte formation and …

TGFβ/BMP signaling pathway in cartilage homeostasis

NGM Thielen, PM van der Kraan, APM van Caam - Cells, 2019 - mdpi.com
Cartilage homeostasis is governed by articular chondrocytes via their ability to modulate
extracellular matrix production and degradation. In turn, chondrocyte activity is regulated by …

[HTML][HTML] Mesenchymal stromal/stem cell-derived extracellular vesicles promote human cartilage regeneration in vitro

LA Vonk, SFJ van Dooremalen, N Liv… - Theranostics, 2018 - ncbi.nlm.nih.gov
Osteoarthritis (OA) is a rheumatic disease leading to chronic pain and disability with no
effective treatment available. Recently, allogeneic human mesenchymal stromal/stem cells …

Polymeric materials for bone and cartilage repair

D Puppi, F Chiellini, AM Piras, E Chiellini - Progress in polymer Science, 2010 - Elsevier
The past decade has seen the rapid development of new strategies for the design of
biodegradable macromolecular compounds, with properly suited architecture and tailored …

TGF-β family signaling in mesenchymal differentiation

I Grafe, S Alexander, JR Peterson… - Cold Spring …, 2018 - cshperspectives.cshlp.org
Mesenchymal stem cells (MSCs) can differentiate into several lineages during development
and also contribute to tissue homeostasis and regeneration, although the requirements for …

Three-dimensional aggregates of mesenchymal stem cells: cellular mechanisms, biological properties, and applications

S Sart, AC Tsai, Y Li, T Ma - Tissue Engineering Part B: Reviews, 2014 - liebertpub.com
Mesenchymal stem cells (MSCs) are primary candidates in cell therapy and tissue
engineering and are being tested in clinical trials for a wide range of diseases. Originally …