Diabetes is a disease that can be treated with oral antidiabetic agents and/or insulin.
However, patients' metabolic control is inadequate in a high percentage of them and a major …

Located between vessels of the choriocapillaris and light-sensitive outer segments of the
photoreceptors, the retinal pigment epithelium (RPE) closely interacts with photoreceptors in …

Age‐related macular degeneration (AMD) is a common cause of visual impairment in the
elderly. There are very limited therapeutic options for AMD with the predominant therapies …

Physical therapists commonly treat people with diabetes for a wide variety of diabetes-
associated impairments, including those from diabetes-related vascular disease. Diabetes is …

The vascular endothelial growth factor (VEGF) family of growth factors controls pathological
angiogenesis and increased vascular permeability in important eye diseases such as …

Collectively, angiogenic ocular conditions represent the leading cause of irreversible vision
loss in developed countries. In the US, for example, retinopathy of prematurity, diabetic …

Diabetic complications are the major cause of morbidity and mortality in persons with
diabetes. Chronic hyperglycemia is a major initiator of diabetic microvascular complications …

Hyperglycemia can promote vascular complications by multiple mechanisms, with formation
of advanced glycation end products and increased oxidative stress proposed to contribute to …

There have been numerous types of animal models of choroidal neovascularization (CNV)
and retinal neovascularization (RNV). Understanding the pathobiology of CNV and RNV is …

Purpose: RNA interference mediated by small interfering RNAs (siRNAs) is a powerful
technology allowing the silencing of mamalian genes with great specificity and potency. The …