Autoimmune and inflammatory uveitis are a group of potentially blinding intraocular
inflammatory diseases that arise without a known infectious trigger and are often associated …

Retinal endothelial cells line the arborizing microvasculature that supplies and drains the
neural retina. The anatomical and physiological characteristics of these endothelial cells are …

T-helper type 17 cells (TH17) are implicated in rodent models of immune-mediated
diseases. Here we report their involvement in human uveitis and scleritis, and validate our …

Objective—Chemokines and their receptors are crucially involved in the development of
atherosclerotic lesions by directing monocyte and T cell recruitment. The CC-chemokine …

Glaucomatous optic neuropathy causes blindness through the degeneration of retinal
ganglion cells (RGCs) and their axons, which comprise the optic nerve. Glaucoma …

Ocular drug delivery remains the focus of much modern research. Primary routes of
administration include the surface, the intravitreal space, the subretinal space, and the …

Uveitis is a sight-threatening disease caused by autoimmune or infection-related immune
responses. Studies in experimental autoimmune uveitis and in human diseases imply that …

The eye and the brain are prototypical tissues manifesting immune privilege (IP) in which
immune responses to foreign antigens, particularly alloantigens are suppressed, and even …

Extracellular vesicles (EVs) derived from mesenchymal stem/stromal cells (MSCs) have
been recognized as promising cytotherapeutics due to their demonstrated …

Immune-mediated inflammation in the retina is regulated by a combination of anatomical,
physiological and immuno-regulatory mechanisms, referred to as the blood–retina barrier …