Abstract The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …

Autophagy is a fundamental catabolic process coordinated by a network of autophagy-
related (ATG) proteins. These ATG proteins also perform an important parallel role in …

Autophagy is a cellular innate-immune defence mechanism against intracellular
microorganisms, including Mycobacterium tuberculosis (Mtb). How canonical and non …

Streptococcus pneumoniae is a leading cause of pneumonia and invasive disease,
particularly, in the elderly. S. pneumoniae lung infection of aged mice is associated with high …

Timely clearance of myelin debris is the premise of neuroinflammation termination and
tissue regeneration in multiple sclerosis (MS). Microglia are the main scavengers of myelin …

Macrophage activation involves metabolic reprogramming to support antimicrobial cellular
functions. How these metabolic shifts influence the outcome of infection by intracellular …

Although autophagy sequesters Mycobacterium tuberculosis (Mtb) in in vitro cultured
macrophages, loss of autophagy in macrophages in vivo does not result in susceptibility to a …

Mycobacterium tuberculosis (Mtb) is a very successful pathogen, strictly adapted to humans
and the cause of tuberculosis. Its success is associated with its ability to inhibit host cell …

Mycobacterium tuberculosis (Mtb) infects several lung macrophage populations, which have
distinct abilities to restrict Mtb. What enables Mtb survival in certain macrophage populations …

SUMMARY Group A Streptococcus (GAS), also known as Streptococcus pyogenes, is a
clinically well-adapted human pathogen that harbors rich virulence determinants …