Antibody-dependent cellular cytotoxicity in HIV infection
DN Forthal, A Finzi - Aids, 2018 - journals.lww.com
Interactions between the Fc segment of IgG and its receptors (FcγRs) found on cells such as
natural killer cells, monocytes, macrophages and neutrophils can potentially mediate …
natural killer cells, monocytes, macrophages and neutrophils can potentially mediate …
[HTML][HTML] Real-time conformational dynamics of SARS-CoV-2 spikes on virus particles
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) mediates
viral entry into cells and is critical for vaccine development against coronavirus disease …
viral entry into cells and is critical for vaccine development against coronavirus disease …
Impact of HIV-1 envelope conformation on ADCC responses
HIV-1 envelope glycoproteins (Env) represent the only virus-specific antigen exposed at the
surface of infected cells. In its unliganded form, Env from primary viruses samples a …
surface of infected cells. In its unliganded form, Env from primary viruses samples a …
The HIV-1 proviral landscape reveals that Nef contributes to HIV-1 persistence in effector memory CD4+ T cells
G Duette, B Hiener, H Morgan… - The Journal of …, 2022 - Am Soc Clin Investig
Despite long-term antiretroviral therapy (ART), HIV-1 persists within a reservoir of CD4+ T
cells that contribute to viral rebound if treatment is interrupted. Identifying the cellular …
cells that contribute to viral rebound if treatment is interrupted. Identifying the cellular …
An asymmetric opening of HIV-1 envelope mediates antibody-dependent cellular cytotoxicity
The HIV-1 envelope glycoprotein (Env)(gp120-gp41) 3 is the target for neutralizing
antibodies and antibody-dependent cellular cytotoxicity (ADCC). HIV-1 Env is flexible …
antibodies and antibody-dependent cellular cytotoxicity (ADCC). HIV-1 Env is flexible …
Comparison of antibody-dependent cell-mediated cytotoxicity and virus neutralization by HIV-1 Env-specific monoclonal antibodies
B von Bredow, JF Arias, LN Heyer, B Moldt… - Journal of …, 2016 - Am Soc Microbiol
Although antibodies to the human immunodeficiency virus type 1 (HIV-1) envelope
glycoprotein have been studied extensively for their ability to block viral infectivity, little data …
glycoprotein have been studied extensively for their ability to block viral infectivity, little data …
Effect of HIV-1 Env on SERINC5 antagonism
ABSTRACT SERINC5 is able to restrict HIV-1 infection by drastically impairing the infectivity
of viral particles. Studies have shown that the HIV-1 Nef protein counters SERINC5 through …
of viral particles. Studies have shown that the HIV-1 Nef protein counters SERINC5 through …
Uninfected bystander cells impact the measurement of HIV-specific antibody-dependent cellular cytotoxicity responses
The conformation of the HIV-1 envelope glycoprotein (Env) substantially impacts antibody
recognition and antibody-dependent cellular cytotoxicity (ADCC) responses. In the absence …
recognition and antibody-dependent cellular cytotoxicity (ADCC) responses. In the absence …
CD4 downregulation precedes Env expression and protects HIV-1-infected cells from ADCC mediated by non-neutralizing antibodies
ABSTRACT HIV-1 envelope glycoprotein (Env) conformation substantially impacts antibody-
dependent cellular cytotoxicity (ADCC). Envs from primary HIV-1 isolates adopt a prefusion …
dependent cellular cytotoxicity (ADCC). Envs from primary HIV-1 isolates adopt a prefusion …
Modulating HIV-1 envelope glycoprotein conformation to decrease the HIV-1 reservoir
Small CD4-mimetic compounds (CD4mc) sensitize HIV-1-infected cells to antibody-
dependent cellular cytotoxicity (ADCC) by facilitating antibody recognition of epitopes that …
dependent cellular cytotoxicity (ADCC) by facilitating antibody recognition of epitopes that …