Opportunities for improved clinical trial designs in acute respiratory distress syndrome

KD Wick, NR Aggarwal, MAQ Curley… - The Lancet …, 2022 - thelancet.com
The acute respiratory distress syndrome (ARDS) is a common critical illness syndrome with
high morbidity and mortality. There are no proven pharmacological therapies for ARDS. The …

Extracorporeal membrane oxygenation without invasive ventilation for respiratory failure in adults: a systematic review

A Belletti, R Sofia, P Cicero, P Nardelli… - Critical Care …, 2023 - journals.lww.com
OBJECTIVES: Extracorporeal membrane oxygenation (ECMO) is an advanced treatment for
acute severe respiratory failure. Patients on ECMO are frequently maintained sedated and …

Acute dyspnea in the emergency department: a clinical review

P Santus, D Radovanovic, M Saad, C Zilianti… - Internal and Emergency …, 2023 - Springer
Acute dyspnea represents one of the most frequent symptoms leading to emergency room
evaluation. Its significant prognostic value warrants a careful evaluation. The differential …

Personalized respiratory support in ARDS: a physiology-to-bedside review

SL Cutuli, DL Grieco, T Michi, M Cesarano… - Journal of Clinical …, 2023 - mdpi.com
Acute respiratory distress syndrome (ARDS) is a leading cause of disability and mortality
worldwide, and while no specific etiologic interventions have been shown to improve …

Noninvasive oxygenation strategies in adult patients with acute hypoxemic respiratory failure: A systematic review and network meta-analysis

T Pitre, D Zeraatkar, GV Kachkovski, G Leung… - Chest, 2023 - Elsevier
Background Several recently published randomized controlled trials have evaluated various
noninvasive oxygenation strategies for the treatment of acute hypoxemic respiratory failure …

Venovenous extracorporeal membrane oxygenation in awake non-intubated patients with COVID-19 ARDS at high risk for barotrauma

G Paternoster, P Bertini, A Belletti, G Landoni… - … of Cardiothoracic and …, 2022 - Elsevier
Objectives: To assess the efficacy of an awake venovenous extracorporeal membrane
oxygenation (VV-ECMO) management strategy in preventing clinically relevant barotrauma …

Clinical use of Macklin-like radiological sign (Macklin effect): A systematic review

A Belletti, O Pallanch, MA Bonizzoni, L Guidi… - Respiratory …, 2023 - Elsevier
Introduction Recent studies suggested that Macklin sign is a predictor of barotrauma in
patients with acute respiratory distress syndrome (ARDS). We performed a systematic …

Spontaneous pneumomediastinum: a surrogate of P-SILI in critically ill COVID-19 patients

A Elabbadi, T Urbina, E Berti, D Contou, G Plantefève… - Critical Care, 2022 - Springer
Spontaneous pneumomediastinum (SP) has been described early during the COVID-19
pandemic in large series of patients with severe pneumonia, but most patients were …

Flow starvation during square-flow assisted ventilation detected by supervised deep learning techniques

C de Haro, V Santos-Pulpón, I Telías, A Xifra-Porxas… - Critical Care, 2024 - Springer
Background Flow starvation is a type of patient-ventilator asynchrony that occurs when gas
delivery does not fully meet the patients' ventilatory demand due to an insufficient airflow …

Clinical applicability of electrical impedance tomography in patient-tailored ventilation: A narrative review

SJH Heines, TH Becher, ICC van der Horst… - Tomography, 2023 - mdpi.com
Electrical Impedance Tomography (EIT) is a non-invasive bedside imaging technique that
provides real-time lung ventilation information on critically ill patients. EIT can potentially …