Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
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CRISPR/Cas systems for genomic modification and gene modulation
F Wu - US Patent 9,738,908, 2017 - Google Patents
The invention relates to engineered CRISPR/Cas9 systems for genomic modification and
regulation of gene expression in mammalian cells. The specification describes the design …
regulation of gene expression in mammalian cells. The specification describes the design …
CRISPR-based genome modification and regulation
F Chen, GD Davis - US Patent 10,731,181, 2020 - Google Patents
The present invention provides RNA-guided endonucleases, which are engineered for
expression in eukaryotic cells or embryos, and methods of using the RNA-guided …
expression in eukaryotic cells or embryos, and methods of using the RNA-guided …
Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence
and, together with a modifying polypeptide, provides for site-specific modification of a target …
and, together with a modifying polypeptide, provides for site-specific modification of a target …
Using truncated guide RNAs (tru-gRNAs) to increase specificity for RNA-guided genome editing
JK Joung, JD Sander, M Maeder, Y Fu - US Patent 9,567,604, 2017 - Google Patents
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Using RNA-guided FokI nucleases (RFNs) to increase specificity for RNA-guided genome editing
JK Joung, S Tsai - US Patent 9,567,603, 2017 - Google Patents
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Compositions and methods directed to CRISPR/Cas genomic engineering systems
F Wu - US Patent 9,234,213, 2016 - Google Patents
The invention relates to engineered CRISPR/Cas9 systems for genomic modification in
mammalian cells. The present specification describes the design and testing of a polynucle …
mammalian cells. The present specification describes the design and testing of a polynucle …
Increasing specificity for RNA-guided genome editing
JK Joung, J Angstman, JD Sander, M Maeder… - US Patent …, 2018 - Google Patents
US9885033B2 - Increasing specificity for RNA-guided genome editing - Google Patents
US9885033B2 - Increasing specificity for RNA-guided genome editing - Google Patents …
US9885033B2 - Increasing specificity for RNA-guided genome editing - Google Patents …
RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
JK Joung, M Maeder - US Patent 10,760,064, 2020 - Google Patents
BACKGROUND Clustered Regulatory Interspaced Short Palindromic Repeats (CRISPR),
and CRISPR-associated (cas) genes, referred to as CRISPR/Cas systems, are used by …
and CRISPR-associated (cas) genes, referred to as CRISPR/Cas systems, are used by …
Using truncated guide RNAs (tru-gRNAs) to increase specificity for RNA-guided genome editing
JK Joung, JD Sander, Y Fu, M Maeder - US Patent 10,119,133, 2018 - Google Patents
CRISPR-Cas genome editing uses a guide RNA, which includes both a complementarity
region, which binds the target DNA by base-pairing, and a Cas9-binding region, to direct a …
region, which binds the target DNA by base-pairing, and a Cas9-binding region, to direct a …