CD8+ T cells are the key executioners of the adaptive immune arm, which mediates
antitumor and antiviral immunity. Naïve CD8+ T cells develop in the thymus and are quickly …

In response to infection, T cells adopt a range of differentiation states, creating numerous
heterogeneous subsets that exhibit different phenotypes, functions, and migration patterns …

Memory CD8+ T cells can be broadly divided into circulating (T CIRCM) and tissue-resident
memory T (T RM) populations. Despite well-defined migratory and transcriptional …

In metazoans, specific tasks are relegated to dedicated organs that are established early in
development, occupy discrete locations and typically remain fixed in size. The adult immune …

Memory CD8 T cells provide durable protection against diverse intracellular pathogens and
can be broadly segregated into distinct circulating and tissue-resident populations …

Background Immune checkpoint blockade (ICB) has significantly prolonged survival of non-
small cell lung cancer (NSCLC) patients, although most patients develop mechanisms of …

During acute infections, CD8+ T cells form various memory subpopulations to provide long-
lasting protection against reinfection. T central memory (TCM), T effector memory (TEM), and …

Formation of long-lasting memory lymphocytes is one of the foundational characteristics of
adaptive immunity and the basis of many vaccination strategies. Following the rapid …

The increasing use of nuclear energy sources inevitably raises the risk of accidental or
deliberate radiation exposure and associated immune dysfunction. However, the extent to …

KLRG1+ CD8 T cells persist for months after clearance of acute infections and maintain high
levels of effector molecules, contributing protective immunity against systemic pathogens …