Host-parasite interactions during Plasmodium infection: Implications for immunotherapies

P Chandley, R Ranjan, S Kumar, S Rohatgi - Frontiers in Immunology, 2023 - frontiersin.org
Malaria is a global infectious disease that remains a leading cause of morbidity and mortality
in the developing world. Multiple environmental and host and parasite factors govern the …

Recent advances in the development of adenovirus-vectored vaccines for parasitic infections

C Koger-Pease, DJ Perera, M Ndao - Pharmaceuticals, 2023 - mdpi.com
Vaccines against parasites have lagged centuries behind those against viral and bacterial
infections, despite the devastating morbidity and widespread effects of parasitic diseases …

A replication-competent smallpox vaccine LC16m8Δ-based COVID-19 vaccine

A Sakamoto, H Osawa, H Hashimoto… - Emerging Microbes & …, 2022 - Taylor & Francis
Viral vectors are a potent vaccine platform for inducing humoral and T-cell immune
responses. Among the various viral vectors, replication-competent ones are less commonly …

Sterile protection and transmission blockade by a multistage anti-malarial vaccine in the pre-clinical study

M Iyori, AM Blagborough, T Mizuno, Y Abe… - Frontiers in …, 2022 - frontiersin.org
The Malaria Vaccine Technology Roadmap 2013 (World Health Organization) aims to
develop safe and effective vaccines by 2030 that will offer at least 75% protective efficacy …

A two-dose viral-vectored Plasmodium vivax multistage vaccine confers durable protection and transmission-blockade in a pre-clinical study

Y Yamamoto, C Fabbri, D Okuhara, R Takagi… - Frontiers in …, 2024 - frontiersin.org
Among Plasmodium spp. responsible for human malaria, Plasmodium vivax ranks as the
second most prevalent and has the widest geographical range; however, vaccine …

Induction of hepatitis E virus anti-ORF3 antibodies from systemic administration of a muscle-specific adeno-associated virus (AAV) vector

L Maurer, J El Andari, K Rapti, L Spreyer, E Steinmann… - Viruses, 2022 - mdpi.com
The hepatitis E virus (HEV) is a major global health problem, leading to large outbreaks in
the developing world and chronic infections in the developed world. HEV is a non …

Adeno-associated virus-based malaria booster vaccine following attenuated replication-competent vaccinia virus LC16m8Δ priming

AA Hasyim, M Iyori, T Mizuno, Y Abe, I Yamagoshi… - Parasitology …, 2023 - Elsevier
We previously demonstrated that boosting with adeno-associated virus (AAV) type 1 (AAV1)
can induce highly effective and long-lasting protective immune responses against malaria …

Vesicular stomatitis virus-based vaccine targeting plasmodium blood-stage antigens elicits immune response and protects against malaria with protein booster …

Y Sun, X Shi, F Lu, H Fu, Y Yin, J Xu, C Jin… - Frontiers in …, 2022 - frontiersin.org
Merozoite invasion of the erythrocytes in humans is a key step in the pathogenesis of
malaria. The proteins involved in the merozoite invasion could be potential targets for the …

Resistance towards ChadOx1 nCoV-19 in an 83 Years Old Woman Experiencing Vaccine Induced Thrombosis with Thrombocytopenia Syndrome

C Gillot, J Favresse, V Maloteau, V Mathieux… - Vaccines, 2022 - mdpi.com
Background: in this report, we describe the case of an 83-year-old woman vaccinated with
ChadOx1 nCoV-19 who developed a so-called vaccine-induced thrombosis with …

Pathogenesis of Plasmodium falciparum

R Noor - Drug Targets for Plasmodium Falciparum: Historic to …, 2024 - Springer
Plasmodium falciparum causes malaria through a complex interaction of parasite-induced
changes in red blood cell (RBC), including microcirculatory abnormalities, immunological …