Prodrugs Design Based on Inter‐and Intramolecular Chemical Processes
R Karaman - Chemical biology & drug design, 2013 - Wiley Online Library
This review provides the reader a concise overview of the majority of prodrug approaches
with the emphasis on the modern approaches to prodrug design. The chemical approach …
with the emphasis on the modern approaches to prodrug design. The chemical approach …
The future of prodrugs–design by quantum mechanics methods
R Karaman, B Fattash, A Qtait - Expert opinion on drug delivery, 2013 - Taylor & Francis
Introduction: The revolution in computational chemistry greatly impacted the drug design
and delivery fields, in general, and recently the utilization of the prodrug approach in …
and delivery fields, in general, and recently the utilization of the prodrug approach in …
[HTML][HTML] Computational repositioning of dimethyl fumarate for treating alcoholic liver disease
Y Zhang, S Zhao, Y Fu, L Yan, Y Feng, Y Chen… - Cell death & …, 2020 - nature.com
Alcoholic liver disease (ALD) is a chronic alcohol-induced disorder of the liver for which
there are few effective therapies for severe forms of ALD and for those who do not achieve …
there are few effective therapies for severe forms of ALD and for those who do not achieve …
Prodrugs of fumarates and their use in treating various diseases
TA Zeidan, S Duncan, CP Hencken, TA Wynn… - US Patent …, 2014 - Google Patents
2,723,967 A 11/1955 Thomas 3,336,364 A 8/1967 Dill 3,580,918 A 5/1971 Bodnarjuk
3,832,287 A 8/1974 Gale et al. 4,515,974 A 5/1985 Zecher et al. 4,639,273 A 1/1987 …
3,832,287 A 8/1974 Gale et al. 4,515,974 A 5/1985 Zecher et al. 4,639,273 A 1/1987 …
The development of a 3D printable chitosan-based copolymer with tunable properties for dentoalveolar regeneration
MS Amoli, R Anand, M EzEldeen, PA Amorim… - Carbohydrate …, 2022 - Elsevier
Dentoalveolar tissue engineering is an emerging yet challenging field, considering the lack
of suitable materials and difficulty to produce patient-specific hydrogel scaffolds. The present …
of suitable materials and difficulty to produce patient-specific hydrogel scaffolds. The present …
Prodrugs of fumarates and their use in treating various diseases
TA Zeidan, S Duncan, CP Hencken, TA Wynn… - US Patent …, 2016 - Google Patents
Int. C. CO7D 49 I/II3(2006.01) C07C 31 7/28(2006.01) CO7D 2II/38(2006.01) C07D
295/088(2006.01) C07D 207/40(2006.01) CO7D 2II/06(2006.01) CO7D 207/06(2006.01) …
295/088(2006.01) C07D 207/40(2006.01) CO7D 2II/06(2006.01) CO7D 207/06(2006.01) …
Prodrugs for masking the bitter taste of drugs
R Karaman - Application of Nanotechnology in Drug Delivery, 2014 - books.google.com
The palatability of the active ingredient of a drug is a significant obstacle in developing a
patient friendly dosage form. Organoleptic properties, such as taste, are an important factor …
patient friendly dosage form. Organoleptic properties, such as taste, are an important factor …
From conventional prodrugs to prodrugs designed by molecular orbital methods
R Karaman - Frontiers in Computational Chemistry, 2015 - Elsevier
In this chapter we attempt to present a novel prodrug approach which is based on enzyme
models that have been advocated to understand the mechanism by which enzymes catalyze …
models that have been advocated to understand the mechanism by which enzymes catalyze …
Prodrugs of fumarates and their use in treating various diseases
TA Zeidan, S Duncan, CP Hencken, TA Wynn… - US Patent …, 2015 - Google Patents
US9090558B2 - Prodrugs of fumarates and their use in treating various diseases - Google
Patents US9090558B2 - Prodrugs of fumarates and their use in treating various diseases …
Patents US9090558B2 - Prodrugs of fumarates and their use in treating various diseases …
Computationally designed prodrugs of statins based on Kirby's enzyme model
Abstract DFT calculations at B3LYP/6-31G (d, p) for intramolecular proton transfer in Kirby's
enzyme models 1–7 demonstrated that the reaction rate is dependent on the distance …
enzyme models 1–7 demonstrated that the reaction rate is dependent on the distance …