How the immune system remembers a previous encounter with a pathogen and responds
more efficiently to a subsequent encounter has been one of the central enigmas for …

Photodynamic therapy (PDT) utilizes the destructive power of reactive oxygen species
generated via visible light irradiation of a photosensitive dye accumulated in the cancerous …

INTRODUCTION Multiple sclerosis (MS) is an inflammatory and degenerative disease of the
central nervous system (CNS) that often presents in young adults. Over the past decade …

Gasdermin D (GSDMD) is considered a proinflammatory factor that mediates pyroptosis in
macrophages to protect hosts from intracellular bacteria. Here, we reveal that GSDMD …

The Immunological Genome Project: networks of gene expression in immune cells | Nature
Immunology Skip to main content Thank you for visiting nature.com. You are using a browser …

The analysis of patient blood transcriptional profiles offers a means to investigate the
immunological mechanisms relevant to human diseases on a genome-wide scale. In …

Abstract Background Dendritic cells (DCs) are a complex group of cells that play a critical
role in vertebrate immunity. Lymph-node resident DCs (LN-DCs) are subdivided into …

Systemic lupus erythematosus (SLE) has a strong but incompletely understood genetic
architecture. We conducted an association study with replication in 4,478 SLE cases and …

Human genetic studies into rheumatoid arthritis (RA) have uncovered more than 100 genetic
loci associated with susceptibility to RA and have refined the RA-association model for HLA …

T and B cell repertoires are collections of lymphocytes, each characterized by its antigen-
specific receptor. We review here classical technologies and analysis strategies developed …