Synthesis of chalcones derivatives and their biological activities: a review

NAA Elkanzi, H Hrichi, RA Alolayan, W Derafa… - ACS …, 2022 - ACS Publications
Chalcone derivatives are considered valuable species because they possess a
ketoethylenic moiety, CO–CH═ CH–. Due to the presence of a reactive α, β-unsaturated …

Metal complexes derived from bidentate ligands: Synthesis, catalytic and biological applications

DI Ugwu, J Conradie - Inorganica Chimica Acta, 2023 - Elsevier
This review focusses on metal complexes containing bidentate ligands. The development in
the synthesis and some applications of these complexes, reported mainly in the last two …

Thiazole-pyrazoline hybrids as potential antimicrobial agent: Synthesis, biological evaluation, molecular docking, DFT studies and POM analysis

RHH Salih, AH Hasan, NH Hussen, FE Hawaiz… - Journal of Molecular …, 2023 - Elsevier
In this study, an efficient synthesis of new thiazole-pyrazoline hybrids was investigated and
hybrids were screened for their antimicrobial activities against four species of pathogenic …

Terminators or guardians? design, synthesis, and cytotoxicity profiling of chalcone-sulfonamide hybrids

SM Aboukhatwa, PA Sidhom, A Angeli, CT Supuran… - ACS …, 2023 - ACS Publications
With a “less is more” philosophy, a series of 15 chalcone-sulfonamide hybrids were
designed anticipating synergistic anticancer activity. The aromatic sulfonamide moiety was …

Design, synthesis, cytotoxic activities, and molecular docking of chalcone hybrids bearing 8-hydroxyquinoline moiety with dual tubulin/EGFR kinase inhibition

MM Amin, GEDA Abuo-Rahma, MSA Shaykoon… - Bioorganic …, 2023 - Elsevier
The present study established thirteen novel 8-hydroxyquinoline/chalcone hybrids 3a–m of
hopeful anticancer activity. According to NCI screening and MTT assay results, compounds …

[HTML][HTML] Anticancer properties of complexes derived from bidentate ligands

DI Ugwu, J Conradie - Journal of Inorganic Biochemistry, 2023 - Elsevier
Cancer is the abnormal division and multiplication of cells in an organ or tissue. It is the
second leading cause of death globally. There are various types of cancer such as prostate …

Significance of Chalcone Scaffolds in Medicinal Chemistry

R Mazumder, Ichudaule, A Ghosh, S Deb… - Topics in Current …, 2024 - Springer
Chalcone is a simple naturally occurring α, β-unsaturated ketone with biological importance,
which can also be easily synthesized in laboratories by reaction between two aromatic …

Synthesis of chalcones and their antimicrobial and drug potentiating activities

ATL Dos Santos, JB de Araújo-Neto, MMC da Silva… - Microbial …, 2023 - Elsevier
The increased resistance of microorganisms to antimicrobial drugs makes it necessary to
search for new active compounds, such as chalcones. Their simple chemical structure …

Synthesis, biological evaluation and molecular docking study of oxindole based chalcone analogues as potent anti-Alzheimer agents

M Taha, H Sadia, F Rahim, MI Khan, S Hayat… - Journal of Molecular …, 2023 - Elsevier
With the goal of developing potential cholinesterase pharmaco-therapeutics, a new class of
thirty analogs oxindole-based chalcone were synthesized by reacting nitro substituted …

Exploring the therapeutic potential of chalcones in oncology: A comprehensive review

CS Yadav, I Azad, AR Khan, N Ahmad… - Current Bioactive …, 2024 - ingentaconnect.com
Chalcone is a bioactive flavonoid found in various plants, such as Angelica archangelica,
Pueraria lobata, and Glycyrrhiza glabra. It has been studied extensively in the field of …