The cyclin dependent kinase Cdk1 controls the cell cycle, which is best understood in the
model organism S. cerevisiae. Research performed during the past decade has significantly …

The SCF (Skp1–Cullin–F-box) E3 ubiquitin ligase family was discovered through genetic
requirements for cell cycle progression in budding yeast. In these multisubunit enzymes, an …

Cell shape is well described by membrane curvature. Septins are filament-forming, GTP-
binding proteins that assemble on positive, micrometer-scale curvatures. Here, we examine …

Polo-like kinases play critical roles during multiple stages of cell cycle progression. All Polo-
like kinases contain an N-terminal Ser/Thr kinase catalytic domain and a C-terminal region …

Septins are an evolutionarily conserved group of GTP‐binding and filament‐forming
proteins that belong to the large superclass of P‐loop GTPases. While originally discovered …

p21-activated kinases (Paks) are a highly conserved family of enzymes that bind to and are
activated by small GTPases of the Cdc42 and Rac families. With the notable exception of …

Studies of the processes leading to the construction of a bud and its separation from the
mother cell in Saccharomyces cerevisiae have provided foundational paradigms for the …

The Wee1 kinase phosphorylates and inhibits cyclin-dependent kinase 1 (Cdk1), thereby
delaying entry into mitosis until appropriate conditions have been met. An understanding of …

At the onset of M phase, the activity of somatic Wee1 (Wee1A), the inhibitory kinase for cyclin-
dependent kinase (CDK), is down-regulated primarily through proteasome-dependent …

Phospholipid-binding modules such as PH, C1, and C2 domains play crucial roles in
location-dependent regulation of many protein kinases. Here, we identify the KA1 domain …