Hemoglobin: structure, function and allostery
This chapter reviews how allosteric (heterotrophic) effectors and natural mutations impact
hemoglobin (Hb) primary physiological function of oxygen binding and transport. First, an …
hemoglobin (Hb) primary physiological function of oxygen binding and transport. First, an …
Serum protein-based nanoparticles for cancer diagnosis and treatment
Serum protein as naturally essential biomacromolecules has recently emerged as a
versatile carrier for diagnostic and therapeutic drug delivery for cancer nanomedicine with …
versatile carrier for diagnostic and therapeutic drug delivery for cancer nanomedicine with …
AlphaFold illuminates half of the dark human proteins
JL Binder, J Berendzen, AO Stevens, Y He… - Current Opinion in …, 2022 - Elsevier
We investigate the use of confidence scores to evaluate the accuracy of a given AlphaFold
(AF2) protein model for drug discovery. Prediction of accuracy is improved by not …
(AF2) protein model for drug discovery. Prediction of accuracy is improved by not …
New look at hemoglobin allostery
Y Yuan, MF Tam, V Simplaceanu, C Ho - Chemical reviews, 2015 - ACS Publications
Hemoglobin (Hb) is a truly remarkable molecule. Human adult hemoglobin (Hb A) has a
tetrameric structure consisting of two α-chains with 141 amino acids each and two β-chains …
tetrameric structure consisting of two α-chains with 141 amino acids each and two β-chains …
Molecular recognition of bio-active flavonoids quercetin and rutin by bovine hemoglobin: an overview of the binding mechanism, thermodynamics and structural …
The binding of two bio-active flavonoids, quercetin and rutin, with bovine hemoglobin (BHb)
was investigated by multi-spectroscopic and computational (molecular docking and …
was investigated by multi-spectroscopic and computational (molecular docking and …
New developments in anti‐sickling agents: can drugs directly prevent the polymerization of sickle haemoglobin in vivo?
E Oder, MK Safo, O Abdulmalik… - British journal of …, 2016 - Wiley Online Library
The hallmark of sickle cell disease is the polymerization of sickle haemoglobin due to a point
mutation in the β‐globin gene (HBB). Under low oxygen saturation, sickle haemoglobin …
mutation in the β‐globin gene (HBB). Under low oxygen saturation, sickle haemoglobin …
Structural and functional insight of sphingosine 1-phosphate-mediated pathogenic metabolic reprogramming in sickle cell disease
Abstract Elevated sphingosine 1-phosphate (S1P) is detrimental in Sickle Cell Disease
(SCD), but the mechanistic basis remains obscure. Here, we report that increased …
(SCD), but the mechanistic basis remains obscure. Here, we report that increased …
A broad diversity in oxygen affinity to haemoglobin
B Balcerek, M Steinach, J Lichti, MA Maggioni… - Scientific reports, 2020 - nature.com
Oxygen affinity to haemoglobin is indicated by the p50 value (pO2 at 50% O2Hb) and
critically determines cellular oxygen availability. Although high Hb-O2 affinity can cause …
critically determines cellular oxygen availability. Although high Hb-O2 affinity can cause …
Identification of lead-binding proteins as carriers and potential molecular targets associated with systolic blood pressure
Q Nong, B Chen, Y Huang, Y Li, Y Wang, L Liu, B He… - Chemosphere, 2023 - Elsevier
Lead (Pb) exposure is well recognized as a significant environmental factor associated with
the high incidence of cardiovascular diseases. However, the carriers and molecular targets …
the high incidence of cardiovascular diseases. However, the carriers and molecular targets …
Therapeutic strategies to alter the oxygen affinity of sickle hemoglobin
The erythrocytes in sickle cell disease have long been known to show decreased oxygen
affinity compared with those from healthy volunteers. 1–4 This property is measured as an …
affinity compared with those from healthy volunteers. 1–4 This property is measured as an …