The blood-brain barrier (BBB) is formed by the endothelial cells of cerebral microvessels,
providing a dynamic interface between the peripheral circulation and the central nervous …

Neural stem cells (NSCs) play vital roles in brain homeostasis and exhibit a broad repertoire
of potentially therapeutic actions following neurovascular injury. One such injury is stroke, a …

VEGF is a secreted mitogen associated with angiogenesis and is also a potent vascular
permeability factor. The biological role of VEGF in the ischemic brain remains unknown. This …

Vascular endothelial growth factor (VEGF) is an angiogenic protein with therapeutic
potential in ischemic disorders, including stroke. VEGF confers neuroprotection and …

The family of vascular endothelial growth factors (VEGFs) are known for their regulation of
vascularization. In the brain, VEGFs are important regulators of angiogenesis …

Sublethal hypoxic or ischemic events can improve the tolerance of tissues, organs, and even
organisms from subsequent lethal injury caused by hypoxia or ischemia. This phenomenon …

We investigated the hypothesis that hypoxia induces angiogenesis and thereby may
counteract the detrimental neurological effects associated with stroke. Forty-eight to seventy …

The development of the nervous and vascular systems constitutes primary events in the
evolution of the animal kingdom; the former provides electrical stimuli and coordination …

Vascular endothelial growth factors (VEGFs) have been shown to participate in
atherosclerosis, arteriogenesis, cerebral edema, neuroprotection, neurogenesis …

The present study investigates the induction of neurogenesis, reduction of apoptosis, and
promotion of basic fibroblast growth factor (bFGF) expression as possible mechanisms by …