Chromosome congression during prometaphase culminates with the establishment of a
metaphase plate, a hallmark of mitosis in metazoans. Classical views resulting from more …

Mitotic spindles are self-organizing protein machines that harness teams of multiple force
generators to drive chromosome segregation. Kinesins are key members of these force …

During metaphase, forces on kinetochores are exerted by k-fibres, bundles of microtubules
that end at the kinetochore. Interestingly, non-kinetochore microtubules have been observed …

Live-cell imaging and particle tracking provide rich information on mechanisms of
intracellular transport. However, trajectory analysis procedures to infer complex transport …

During metaphase, chromosome position at the spindle equator is regulated by the forces
exerted by kinetochore microtubules and polar ejection forces. However, the role of forces …

Mitotic spindle microtubules (MT s) undergo continuous poleward flux, whose driving force
and function in humans remain unclear. Here, we combined loss‐of‐function screenings …

The spindle is a dynamic self-assembling machine that coordinates mitosis. The spindle's
function depends on its ability to organize microtubules into poles and maintain pole …

The mitotic spindle is a microtubule-based assembly that separates the chromosomes
during cell division. As the spindle is basically a mechanical micro machine, the …

In the mitotic spindle, kinetochore microtubules form k‐fibers, whereas overlap or interpolar
microtubules form antiparallel arrays containing the cross‐linker protein regulator of …

Cell division requires the wholesale reorganization of cell architecture. At the same time as
the microtubule network is remodelled to generate a bipolar spindle, animal cells entering …