2, 5-Diketopiperazines: synthesis, reactions, medicinal chemistry, and bioactive natural products
AD Borthwick - Chemical reviews, 2012 - ACS Publications
2, 5-Diketopiperazines (2, 5-DKPs) are cyclodipeptides obtained by the condensation of two
α-amino acids. They not only abound in nature but are often produced as degradation …
α-amino acids. They not only abound in nature but are often produced as degradation …
Indoles in multicomponent processes (MCPs)
M Shiri - Chemical reviews, 2012 - ACS Publications
In the last two or three decades the emphasis on and applications of green chemical
principles, introduced some significant advances in organic synthesis, such as combinatorial …
principles, introduced some significant advances in organic synthesis, such as combinatorial …
Lead‐oriented synthesis: a new opportunity for synthetic chemistry
A Nadin, C Hattotuwagama… - Angewandte Chemie …, 2012 - Wiley Online Library
The pharmaceutical industry remains solely reliant on synthetic chemistry methodology to
prepare compounds for small‐molecule drug discovery programmes. The importance of the …
prepare compounds for small‐molecule drug discovery programmes. The importance of the …
[HTML][HTML] Isocyanide-based multicomponent reactions towards cyclic constrained peptidomimetics
G Koopmanschap, E Ruijter… - Beilstein Journal of …, 2014 - beilstein-journals.org
In the recent past, the design and synthesis of peptide mimics (peptidomimetics) has
received much attention. This because they have shown in many cases enhanced …
received much attention. This because they have shown in many cases enhanced …
Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones by Three-Component Coupling of Isatoic Anhydride, Amines, and Aldehydes Catalyzed by Magnetic Fe3O4 …
ZH Zhang, HY Lu, SH Yang… - Journal of combinatorial …, 2010 - ACS Publications
A simple and efficient protocol for one-pot three-component coupling of isatoic anhydride,
amines, and aldehydes in water using magnetically recoverable Fe3O4 nanoparticles is …
amines, and aldehydes in water using magnetically recoverable Fe3O4 nanoparticles is …
Cyclic dipeptide: A privileged molecular scaffold to derive structural diversity and functional utility
Cyclic dipeptides (CDPs) are the simplest form of cyclic peptides with a wide range of
applications from therapeutics to biomaterials. CDP is a versatile molecular platform …
applications from therapeutics to biomaterials. CDP is a versatile molecular platform …
Recent advances in asymmetric isocyanide‐based multicomponent reactions
SS van Berkel, BGM Bögels… - European Journal of …, 2012 - Wiley Online Library
Isocyanide‐based multicomponent reactions (IMCRs) can be considered one of the
breakthrough reaction classes of the last century. Moreover, asymmetric IMCRs have …
breakthrough reaction classes of the last century. Moreover, asymmetric IMCRs have …
Combinatorial synthesis, in silico, molecular and biochemical studies of tetrazole-derived organic selenides with increased selectivity against hepatocellular …
S Shaaban, A Negm, AM Ashmawy, DM Ahmed… - European Journal of …, 2016 - Elsevier
Novel tetrazole-based diselenides and selenoquinones were synthesized via azido-Ugi and
sequential nucleophilic substitution (SN) strategy. Molecular docking study into mammalian …
sequential nucleophilic substitution (SN) strategy. Molecular docking study into mammalian …
2, 5-diketopiperazines in food and beverages: Taste and bioactivity
AD Borthwick, NC Da Costa - Critical reviews in food science and …, 2017 - Taylor & Francis
Diketopiperazines (2, 5-DKPs) have been found to occur in a wide range of food and
beverages, and display an array of chemesthetic effects (bitter, astringent, metallic, and …
beverages, and display an array of chemesthetic effects (bitter, astringent, metallic, and …
[HTML][HTML] Complexity from simplicity: the Ugi-Aldol sequence as an expeditious entry into several families of densely substituted N-heterocylces
Z Xu, F De Moliner, AP Cappelli… - … Chemie (International ed …, 2012 - ncbi.nlm.nih.gov
All it takes is the Aldol—Nitrogen containing heterocycles have been assembled by means
of unprecedented domino processes, designed to take advantage of diversity assembly via …
of unprecedented domino processes, designed to take advantage of diversity assembly via …