The past 20 years have witnessed an impressive expansion of the 'drug space'; defined as
the intersection of the Medicinal Chemistry space and the Biologically Active space relevant …

Rapid in silico selection of target focused libraries from commercial repositories is an
attractive and cost-effective approach in early drug discovery. If structures of active …

Protein kinases constitute an attractive family of enzyme targets with high relevance to cell
and disease biology. Small molecule inhibitors are powerful tools to dissect and elucidate …

Rapid in silico selection of target focused libraries from commercial repositories is an
attractive and cost effective approach. If structures of active compounds are available rapid …

Background The current chemical space of known small molecules is estimated to exceed
10 60 structures. Though the largest physical compound repositories contain only a few tens …

Epigenetic modifications are critical mechanisms that regulate many biological processes
and establish normal cellular phenotypes. Aberrant epigenetic modifications are frequently …

Rapid in silico selection of target focused libraries from commercial repositories is an
attractive and cost-effective approach when starting new drug discovery projects. If …

The drug discovery process mainly relies on the experimental high-throughput screening of
huge compound libraries in their pursuit of new active compounds. However, spiraling …

The regioselective palladium-catalyzed cross-coupling reactions of 2, 4, 7-
trichloroquinazoline with various aryl-and heteroarylboronic acids are reported. An efficient …

Publisher Summary This chapter provides an overview of the strategies that have been
developed for the selection and synthesis of compounds for collection enhancement and …