The crucial role and mechanism of insulin resistance in metabolic disease

X Zhao, X An, C Yang, W Sun, H Ji… - Frontiers in endocrinology, 2023 - frontiersin.org
Insulin resistance (IR) plays a crucial role in the development and progression of
metabolism-related diseases such as diabetes, hypertension, tumors, and nonalcoholic fatty …

Obstructive sleep apnea and comorbidities: a dangerous liaison

MR Bonsignore, P Baiamonte, E Mazzuca… - Multidisciplinary …, 2019 - Springer
Obstructive sleep apnea (OSA) is a highly prevalent disease, and is traditionally associated
with increased cardiovascular risk. The role of comorbidities in OSA patients has emerged …

Mechanisms of insulin resistance in obesity

J Ye - Frontiers of medicine, 2013 - Springer
Obesity increases the risk for type 2 diabetes through induction of insulin resistance.
Treatment of type 2 diabetes has been limited by little translational knowledge of insulin …

Obstructive sleep apnea: a cardiometabolic risk in obesity and the metabolic syndrome

LF Drager, SM Togeiro, VY Polotsky… - Journal of the American …, 2013 - jacc.org
Obstructive sleep apnea (OSA) is an underdiagnosed condition characterized by recurrent
episodes of obstruction of the upper airway leading to sleep fragmentation and intermittent …

International consensus statement on obstructive sleep apnea

JL Chang, AN Goldberg, JA Alt… - International forum of …, 2023 - Wiley Online Library
Background Evaluation and interpretation of the literature on obstructive sleep apnea (OSA)
allows for consolidation and determination of the key factors important for clinical …

Pathophysiology of sleep apnea

JA Dempsey, SC Veasey, BJ Morgan… - Physiological …, 2010 - journals.physiology.org
Sleep-induced apnea and disordered breathing refers to intermittent, cyclical cessations or
reductions of airflow, with or without obstructions of the upper airway (OSA). In the presence …

Hypoxia and adipose tissue function and dysfunction in obesity

P Trayhurn - Physiological reviews, 2013 - journals.physiology.org
The rise in the incidence of obesity has led to a major interest in the biology of white adipose
tissue. The tissue is a major endocrine and signaling organ, with adipocytes, the …

Obstructive sleep apnea, hypoxia, and nonalcoholic fatty liver disease

OA Mesarwi, R Loomba, A Malhotra - American journal of …, 2019 - atsjournals.org
Recent studies have demonstrated that obstructive sleep apnea (OSA) is associated with the
development and evolution of nonalcoholic fatty liver disease (NAFLD), independent of …

Obstructive sleep apnoea syndrome

P Lévy, M Kohler, WT McNicholas, F Barbé… - Nature reviews Disease …, 2015 - nature.com
Obstructive sleep apnoea syndrome (OSAS) is a common clinical condition in which the
throat narrows or collapses repeatedly during sleep, causing obstructive sleep apnoea …

The impact of sleep disorders on glucose metabolism: endocrine and molecular mechanisms

A Briançon-Marjollet, M Weiszenstein, M Henri… - Diabetology & metabolic …, 2015 - Springer
Modern lifestyle has profoundly modified human sleep habits. Sleep duration has shortened
over recent decades from 8 to 6.5 hours resulting in chronic sleep deprivation. Additionally …