Once known exclusively for their role in nutrients absorption, primary bile acids,
chenodeoxycholic and cholic acid, and secondary bile acids, deoxycholic and lithocholic …

Bile acids have received considerable interest in the drug delivery research due to their
peculiar physicochemical properties and biocompatibility. The main advantage of bile acids …

Objective Non-alcoholic fatty liver disease (NAFLD)-associated hepatocellular carcinoma
(HCC) is an increasing healthcare burden worldwide. We examined the role of dietary …

Introduction Increasing evidence suggests a role for the gut microbiome in central nervous
system disorders and a specific role for the gut-brain axis in neurodegeneration. Bile acids …

Conclusions This study demonstrates that E. multilocularis can induce T‐cell exhaustion
through inhibitory receptor TIGIT, and that blocking this checkpoint may reverse the …

Chronic jet lag induces spontaneous hepatocellular carcinoma (HCC) in wild-type mice
following a mechanism very similar to that observed in obese humans. The process initiates …

Bile acids are potent antibacterial compounds and play an important role in shaping the
microbial ecology of the gut. Here, we combined flow cytometry, growth rate measurements …

Abstract Background and Aims The prevalence of nonalcoholic fatty liver disease (NAFLD)
and steatohepatitis (NASH) is increasing at an alarming rate. The role of bile acids in the …

Bile acids were first proposed as carcinogens in 1939. Since then, accumulated evidence
has linked exposure of cells of the gastrointestinal tract to repeated high physiologic levels …

The use of animal models, particularly genetically modified mice, continues to play a critical
role in studying the relationship between bile acid metabolism and human liver disease …