Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

Exercise mimetics are a proposed class of therapeutics that specifically mimic or enhance
the therapeutic effects of exercise. Increased physical activity has demonstrated positive …

Sarcopenia is a geriatric syndrome characterized by the progressive degeneration of muscle
mass and function, and it is associated with severe complications, which are falls, functional …

Objective The relationship between physical activity (PA) and the risk of frailty has not
reached a conclusive result. This systematic review with meta-analysis aimed to evaluate …

Klotho is a critical protein that protects the kidney. Klotho is severely downregulated in
chronic kidney disease (CKD), and its deficiency is implicated in the pathogenesis and …

Abstract Purpose of Review Osteoarthritis (OA) is a subset of joint disorders resulting in
degeneration of synovial joints. This leads to pain, disability and loss of independence …

ABSTRACT MATTIONI MATURANA, F., P. MARTUS, S. ZIPFEL, and AM NIEß. Effectiveness
of HIIE versus MICT in Improving Cardiometabolic Risk Factors in Health and Disease: A …

We sought to determine the skeletal muscle genome-wide DNA methylation and mRNA
responses to one bout of lower load (LL) versus higher load (HL) resistance exercise …

Exercise training is continually challenging whole-body homeostasis, leading to
improvements in performance and health. Adaptations to exercise training are complex and …

Aging is an inevitable and gradually progressive process affecting all organs and systems.
The musculoskeletal system makes no exception, elderly exhibit an increased risk of …