The potential dangers of using viruses to deliver and integrate DNA into host cells in gene
therapy have been poignantly highlighted in recent clinical trials. Safer, non-viral gene …

An enormous body of work generated over the past three decades has revealed that
eukaryotic gene transcription is a remarkably intricate biochemical process that is tightly …

Satb2 is a DNA-binding protein that regulates chromatin organization and gene expression.
In the developing brain, Satb2 is expressed in cortical neurons that extend axons across the …

Vertebrate skeletogenesis involves two processes, skeletal patterning and osteoblast
differentiation. Here, we show that Satb2, encoding a nuclear matrix protein, is expressed in …

The AT-hook is a small DNA-binding protein motif which was first described in the high
mobility group non-histone chromosomal protein HMG-I (Y). Since its discovery, this motif …

Eukaryotic chromosomes are organized inside the nucleus in such a way that only a subset
of the genome is expressed in any given cell type, but the details of this organization are …

SATB1 is expressed primarily in thymocytes and can act as a transcriptional repressor.
SATB1 binds in vivo to the matrix attachment regions (MARs) of DNA, which are implicated …

Eukaryotic chromosomes are packaged in nuclei by many orders of folding. Little is known
about how higher-order chromatin packaging might affect gene expression. SATB1 is a cell …

Locus control regions (LCRs) are defined by their ability, in transgenic assays, to direct high-
level, tissue-specific expression of linked genes at all sites of integration examined and at …

The SAP family transcription factor myocardin functionally synergizes with serum response
factor (SRF) and plays an important role in cardiac development. To determine the function …