The RAS GTPases are frequently mutated in human cancer, with KRAS being the
predominant tumor driver. For many years, it has been known that the structure and function …

The structure-function paradigm has guided investigations into the molecules involved in
cellular signalling for decades. The peripheries of this paradigm, however, start to unravel …

Abstract ADP-ribosylation factor 1 (Arf1) interacts with multiple cellular partners and
membranes to regulate intracellular traffic, organelle structure and actin dynamics. Defining …

Protein–membrane interactions (PMIs) are ubiquitous in cellular signaling. Initial steps of
signal transduction cascades often rely on transient and dynamic interactions with the inner …

Ras dimerization is critical for Raf activation. Here we show that the Ras binding domain of
Raf (Raf-RBD) induces robust Ras dimerization at low surface densities on supported lipid …

Ras acts as a molecular switch to control intracellular signaling on the plasma membrane
(PM). Elucidating how Ras associates with PM in the native cellular environment is crucial …

Abstract Self‐assemblies (ie, nanoclusters) of the RAS GTPase on the membrane act as
scaffolds that activate downstream RAF kinases and drive MAPK signaling for cell …

KRAS forms transient dimers and higher-order multimers (nanoclusters) on the plasma
membrane, which drive MAPK signaling and cell proliferation. KRAS is a frequently mutated …

Ras is the most frequently mutated oncogene and recent drug development efforts have
spurred significant new research interest. Here we review progress toward understanding …

The appeal of multiscale modeling approaches is predicated on the promise of
combinatorial synergy. However, this promise can only be realized when distinct scales are …