RNA-based therapy is a promising and potential strategy for disease treatment by
introducing exogenous nucleic acids such as messenger RNA (mRNA), small interfering …

This Perspective focuses on thiol-mediated uptake, that is, the entry of substrates into cells
enabled by oligochalcogenides or mimics, often disulfides, and inhibited by thiol-reactive …

Efficient viral or nonviral delivery of nucleic acids is the key step of genetic nanomedicine.
Both viral and synthetic vectors have been successfully employed for genetic delivery with …

Nanotechnology-based RNA interference (RNAi) has shown great promise in overcoming
the limitations of traditional clinical treatments for glioblastoma (GBM). However, because of …

Biopharmaceuticals have emerged to play a vital role in disease treatment and have shown
promise in the rapidly expanding pharmaceutical market due to their high specificity and …

Small interfering RNA (siRNA) has been considered as a highly promising therapeutic agent
for human cancer treatment including glioblastoma (GBM), which is a fatal disease without …

Proteins, a type of natural biopolymer that possess many prominent merits, have been
widely utilized to engineer nanomedicine for fighting against cancer. Motivated by their ever …

Small interfering RNA (siRNA) therapy has been considered as a promising strategy for
treatment of glioblastoma (GBM), which is an aggressive brain disease with poor prognosis …

Oligonucleotide phosphorothioates (OPS) are DNA or RNA mimics where one phosphate
oxygen is replaced by a sulfur atom. They have been shown to enter mammalian cells much …

The blood–brain barrier (BBB) is the most important obstacle to improving the clinical
outcomes of diagnosis and therapy of glioblastoma. Thus, the development of a novel …