[HTML][HTML] Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration
K Kaarniranta, H Uusitalo, J Blasiak… - Progress in retinal and …, 2020 - Elsevier
Oxidative stress-induced damage to the retinal pigment epithelium (RPE) is considered to
be a key factor in age-related macular degeneration (AMD) pathology. RPE cells are …
be a key factor in age-related macular degeneration (AMD) pathology. RPE cells are …
Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration
K Kaarniranta, D Sinha, J Blasiak, A Kauppinen… - Autophagy, 2013 - Taylor & Francis
Age-related macular degeneration (AMD) is a complex, degenerative and progressive eye
disease that usually does not lead to complete blindness, but can result in severe loss of …
disease that usually does not lead to complete blindness, but can result in severe loss of …
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy
C Vives-Bauza, C Zhou, Y Huang… - Proceedings of the …, 2010 - National Acad Sciences
Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1) and
PARK2/Parkin mutations cause autosomal recessive forms of Parkinson's disease. Upon a …
PARK2/Parkin mutations cause autosomal recessive forms of Parkinson's disease. Upon a …
[HTML][HTML] Noncanonical autophagy promotes the visual cycle
JY Kim, H Zhao, J Martinez, TA Doggett, AV Kolesnikov… - Cell, 2013 - cell.com
Phagocytosis and degradation of photoreceptor outer segments (POS) by retinal pigment
epithelium (RPE) is fundamental to vision. Autophagy is also responsible for bulk …
epithelium (RPE) is fundamental to vision. Autophagy is also responsible for bulk …
Defects in retinal pigment epithelial cell proteolysis and the pathology associated with age-related macular degeneration
DA Ferrington, D Sinha, K Kaarniranta - Progress in retinal and eye …, 2016 - Elsevier
Maintenance of protein homeostasis, also referred to as “Proteostasis”, integrates multiple
pathways that regulate protein synthesis, folding, translocation, and degradation. Failure in …
pathways that regulate protein synthesis, folding, translocation, and degradation. Failure in …
Structure and function of ABCA4 and its role in the visual cycle and Stargardt macular degeneration
RS Molday, FA Garces, JF Scortecci… - Progress in retinal and eye …, 2022 - Elsevier
ABCA4 is a member of the superfamily of ATP-binding cassette (ABC) transporters that is
preferentially localized along the rim region of rod and cone photoreceptor outer segment …
preferentially localized along the rim region of rod and cone photoreceptor outer segment …
[HTML][HTML] mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice
C Zhao, D Yasumura, X Li, M Matthes… - The Journal of …, 2011 - Am Soc Clin Investig
Retinal pigment epithelial (RPE) cell dysfunction plays a central role in various retinal
degenerative diseases, but knowledge is limited regarding the pathways responsible for …
degenerative diseases, but knowledge is limited regarding the pathways responsible for …
Mitochondria as potential targets and initiators of the blue light hazard to the retina
JX Tao, WC Zhou, XG Zhu - Oxidative medicine and cellular …, 2019 - Wiley Online Library
Commercially available white light‐emitting diodes (LEDs) have an intense emission in the
range of blue light, which has raised a range of public concerns about their potential risks as …
range of blue light, which has raised a range of public concerns about their potential risks as …
Transcriptome analysis and molecular signature of human retinal pigment epithelium
NV Strunnikova, A Maminishkis, JJ Barb… - Human molecular …, 2010 - academic.oup.com
Retinal pigment epithelium (RPE) is a polarized cell layer critical for photoreceptor function
and survival. The unique physiology and relationship to the photoreceptors make the RPE a …
and survival. The unique physiology and relationship to the photoreceptors make the RPE a …
Unraveling a multifactorial late-onset disease: from genetic susceptibility to disease mechanisms for age-related macular degeneration
Aging-associated neurodegenerative diseases significantly influence the quality of life of
affected individuals. Genetic approaches, combined with genomic technology, have …
affected individuals. Genetic approaches, combined with genomic technology, have …