Heparin has been recognized as a valuable anticoagulant and antithrombotic for several
decades and is still widely used in clinical practice for a variety of indications. The …

Heparan sulfate (HS) proteoglycans (PGs) are ubiquitously expressed on cell surfaces and
in the extracellular matrix of most animal tissues, having essential functions in development …

▪ Abstract Immune modulators such as cytokines and growth factors exert their biological
activity through high-affinity interactions with cell-surface receptors, thereby activating …

Heparan sulfate (HS) proteoglycans at cell surfaces and in the extracellular matrix of most
animal tissues are essential in development and homeostasis, and variously implicated in …

Glycosaminoglycans (GAGs) play a crucial role in tissue homeostasis by regulating the
activity and diffusion of bioactive molecules. Incorporating GAGs into biomaterials has …

Over the past decade, the glycosaminoglycans heparin and heparan sulfate have been
shown to bind and regulate the activities of many proteins. Established techniques have …

Heparan sulfate (HS) proteoglycans at the cell surface and in the extracellular matrix of most
animal tissues are essential in development and homeostasis, and are implicated in disease …

The essential role of protein–glycosaminoglycan interactions in the regulation of various
physiological processes has been recognized for several decades but it is only recently that …

Glycosaminoglycans are polysaccharides that occur both at the cell surface and within
extracellular matrices. Through their ability to bind to a large array of proteins, almost 500 of …

In a recent study, we demonstrated that glycosaminoglycan (GAG) binding and
oligomerization are essential for the in vivo function of the chemokines MCP-1/CCL2 …