Post-translational modifications (PTM) decorate proteins to provide functional heterogeneity
to an existing proteome. The large number of known PTMs highlights the many ways that …

The GCN5-related N-acetyltransferases family (GNAT) is an important family of proteins that
includes more than 100000 members among eukaryotes and prokaryotes. Acetylation …

Mycobacterium tuberculosis (Mtb) relies on a specialized set of metabolic pathways to
support growth in macrophages. By conducting an extensive, unbiased chemical screen to …

Acylation of biomolecules (eg, proteins and small molecules) is a process that occurs in cells
of all domains of life and has emerged as a critical mechanism for the control of many …

N ɛ-Acetylation of lysine residues represents a pivotal post-translational modification used
by both eukaryotes and prokaryotes to modulate diverse biological processes …

The lysine acetylation of proteins is a reversible post-translational modification that plays a
critical regulatory role in both eukaryotes and prokaryotes. Mycobacterium tuberculosis is a …

Despite the deployment of combination tuberculosis (TB) chemotherapy, efforts to identify
shorter, nonrelapsing treatments have resulted in limited success. Recent evidence …

Nucleoid‐associated protein HU, a conserved protein across eubacteria is necessary for
maintaining the nucleoid organization and global regulation of gene expression …

Cyclic AMP (cAMP) is a ubiquitous second messenger that transduces signals from cellular
receptors to downstream effectors. Mycobacterium tuberculosis (Mtb), the etiological agent …

Tuberculosis (TB) is one of the primary causes of deaths due to infectious diseases. The
current TB regimen is long and complex, failing of which leads to relapse and/or the …