Impact of curcumin on sirtuins: A review
Curcumin is a bioactive phytochemical that modulates several physiological and cellular
processes leading to therapeutic effects against different diseases. Sirtuins are highly …
processes leading to therapeutic effects against different diseases. Sirtuins are highly …
Selective inhibition of SIRT2: A disputable therapeutic approach in cancer therapy
Abstract Sirtuin 2 (SIRT2) is involved in a wide range of processes, from transcription to
metabolism to genome stability. Dysregulation of SIRT2 has been associated with the …
metabolism to genome stability. Dysregulation of SIRT2 has been associated with the …
Nicotinamide inhibits melanoma in vitro and in vivo
F Scatozza, F Moschella, D D'Arcangelo… - Journal of Experimental …, 2020 - Springer
Background Even though new therapies are available against melanoma, novel approaches
are needed to overcome resistance and high-toxicity issues. In the present study the anti …
are needed to overcome resistance and high-toxicity issues. In the present study the anti …
Golgi stress induces SIRT2 to counteract Shigella infection via defatty-acylation
Enzymes from pathogens often modulate host protein post-translational modifications
(PTMs), facilitating survival and proliferation of pathogens. Shigella virulence factors IpaJ …
(PTMs), facilitating survival and proliferation of pathogens. Shigella virulence factors IpaJ …
Simultaneous inhibition of SIRT2 deacetylase and defatty-acylase activities via a PROTAC strategy
As a member of the sirtuin family of enzymes, SIRT2 promotes tumor growth and regulates
various biological pathways through lysine deacetylation and defatty-acylation. In the past …
various biological pathways through lysine deacetylation and defatty-acylation. In the past …
An allosteric inhibitor of sirtuin 2 deacetylase activity exhibits broad-spectrum antiviral activity
KL Roche, S Remiszewski, MJ Todd… - The Journal of …, 2023 - Am Soc Clin Investig
Most drugs used to treat viral disease target a virus-coded product. They inhibit a single
virus or virus family, and the pathogen can readily evolve resistance. Host-targeted antivirals …
virus or virus family, and the pathogen can readily evolve resistance. Host-targeted antivirals …
Potent mechanism-based sirtuin-2-selective inhibition by an in situ-generated occupant of the substrate-binding site,“selectivity pocket” and NAD+-binding site
P Mellini, Y Itoh, H Tsumoto, Y Li, M Suzuki… - Chemical …, 2017 - pubs.rsc.org
Sirtuin 2 (SIRT2), a member of the NAD+-dependent histone deacetylase family, has
recently received increasing attention due to its potential involvement in neurodegenerative …
recently received increasing attention due to its potential involvement in neurodegenerative …
A small‐molecule SIRT2 inhibitor that promotes K‐Ras4a lysine fatty‐acylation
SIRT2, a member of the sirtuin family of protein lysine deacylases, has been identified as a
promising therapeutic target for treating cancer. In addition to catalyzing deacetylation …
promising therapeutic target for treating cancer. In addition to catalyzing deacetylation …
Novel lysine-based thioureas as mechanism-based inhibitors of sirtuin 2 (SIRT2) with anticancer activity in a colorectal cancer murine model
Sirtuin 2 (SIRT2) is a protein lysine deacylase that has been indicated as a therapeutic
target for cancer. To further establish the role of SIRT2 in cancers, it is necessary to develop …
target for cancer. To further establish the role of SIRT2 in cancers, it is necessary to develop …
Identification of a novel small molecule that inhibits deacetylase but not defatty-acylase reaction catalysed by SIRT2
SIRT2 is a member of the human sirtuin family of proteins and possesses NAD+-dependent
lysine deacetylase/deacylase activity. SIRT2 has been implicated in carcinogenesis in …
lysine deacetylase/deacylase activity. SIRT2 has been implicated in carcinogenesis in …