Cholangiocytes, the epithelial cells lining the intrahepatic and extrahepatic bile ducts, are
highly specialized cells residing in a complex anatomic niche where they participate in bile …

The liver is a key organ that plays a pivotal role in metabolism and ensures a variety of
functions in the body, including homeostasis, synthesis of essential components, nutrient …

In vitro liver cell culture models are gaining increasing importance in pharmacological and
toxicological research. The source of cells used is critical for the relevance and the …

Recent development of improved tools and methods to analyse tissues at the three-
dimensional level has expanded our capacity to investigate morphogenesis of foetal liver …

Bile salts represent signalling molecules with a variety of endocrine functions. Bile salt
effects are mediated by different receptor molecules, comprising ligand-activated nuclear …

Pediatric liver transplantation is often required as a consequence of biliary disorders
because of the lack of alternative treatments for repairing or replacing damaged bile ducts …

Liver transplantation is the most common treatment for patients suffering from liver failure
that is caused by congenital diseases, infectious agents, and environmental factors. Despite …

The burden of liver diseases is increasing worldwide, with liver transplantation remaining
the only treatment option for end‐stage liver disease. Regenerative medicine holds great …

The involvement of the biliary tract in the pathophysiology of liver diseases and the
increased attention paid to bile ducts in the bioconstruction of liver tissue for regenerative …

Background & Aims Cholangiocarcinoma (CCA) is a biliary malignancy linked to genetic
and epigenetic abnormalities, such as hypermethylation of SOX17 promoter. Here, the role …