Beyond R0 maximisation: on pathogen evolution and environmental dimensions
S Lion, JAJ Metz - Trends in ecology & evolution, 2018 - cell.com
A widespread tenet is that evolution of pathogens maximises their basic reproduction ratio,
R 0. The breakdown of this principle is typically discussed as exception. Here, we argue that …
R 0. The breakdown of this principle is typically discussed as exception. Here, we argue that …
Viral invasion fitness across a continuum from lysis to latency
The prevailing paradigm in ecological studies of viruses and their microbial hosts is that the
reproductive success of viruses depends on the proliferation of the 'predator', that is, the …
reproductive success of viruses depends on the proliferation of the 'predator', that is, the …
When to be temperate: on the fitness benefits of lysis vs. lysogeny
Bacterial viruses, that is 'bacteriophage'or 'phage', can infect and lyse their bacterial hosts,
releasing new viral progeny. In addition to the lytic pathway, certain bacteriophage (ie …
releasing new viral progeny. In addition to the lytic pathway, certain bacteriophage (ie …
Evolution of pathogen virulence across space during an epidemic
EE Osnas, PJ Hurtado… - The American …, 2015 - journals.uchicago.edu
We explore pathogen virulence evolution during the spatial expansion of an infectious
disease epidemic in the presence of a novel host movement trade-off, using a simple …
disease epidemic in the presence of a novel host movement trade-off, using a simple …
A practical approach to R0 in continuous‐time ecological models
In this paper we study the asymptotic behaviour of the solutions in linear models of
population dynamics by means of the basic reproduction number R 0. Our aim is to give a …
population dynamics by means of the basic reproduction number R 0. Our aim is to give a …
Pathogen evolution in finite populations: slow and steady spreads the best
The theory of life-history evolution provides a powerful framework to understand the
evolutionary dynamics of pathogens. It assumes, however, that host populations are large …
evolutionary dynamics of pathogens. It assumes, however, that host populations are large …
On the reproduction number of a gut microbiota model
A spatially structured linear model of the growth of intestinal bacteria is analysed from two
generational viewpoints. Firstly, the basic reproduction number associated with the bacterial …
generational viewpoints. Firstly, the basic reproduction number associated with the bacterial …
Evolutionary dynamics of infectious diseases in finite populations
In infectious disease epidemiology the basic reproductive ratio, R 0, is defined as the
average number of new infections caused by a single infected individual in a fully …
average number of new infections caused by a single infected individual in a fully …
Pathogen evolution under host avoidance plasticity
Host resistance consists of defences that limit pathogen burden, and can be classified as
either adaptations targeting recovery from infection or those focused upon infection …
either adaptations targeting recovery from infection or those focused upon infection …
Building new models: Rethinking and revising ode model assumptions
PJ Hurtado - An Introduction to Undergraduate Research in …, 2020 - Springer
Abstract Ordinary Differential Equation (ODE) models are ubiquitous throughout the
sciences, and form the backbone of the branch of mathematics known as applied dynamical …
sciences, and form the backbone of the branch of mathematics known as applied dynamical …