Inflammation is a cellular response to factors that challenge the homeostasis of cells and
tissues. Cell-associated and soluble pattern-recognition receptors, eg Toll-like receptors …

Age-related macular degeneration (AMD) is a multifactorial disease influenced by a
combination of environmental factors and genetic variants. Genomic studies have been …

Stable isotope labeling by amino acids in cell culture (SILAC) is a simple, robust, yet
powerful approach in mass spectrometry (MS)-based quantitative proteomics. SILAC labels …

Age-related macular degeneration (AMD) is a disease that affects the macula–the central
part of the retina. It is a leading cause of irreversible vision loss in the elderly. AMD onset is …

PURPOSE: To present the current understanding of age-related macular degeneration
(AMD) pathogenesis, based on clinical evidence, epidemiologic data, histopathologic …

Background Age-related macular degeneration (AMD) is a leading cause of blindness that
affects the central region of the retinal pigmented epithelium (RPE), choroid, and neural …

Retinal pigment epithelial (RPE) cells form a monolayer between the neuroretina and
choroid. It has multiple important functions, including acting as outer blood-retina barrier …

Age-related macular degeneration (AMD) affects the retinal pigment epithelium (RPE), a cell
monolayer essential for photoreceptor survival, and is the leading cause of vision loss in the …

OBJECTIVE—Obesity is associated with endocrine abnormalities that predict the
progression of insulin resistance to type 2 diabetes. Because skeletal muscle has been …

We introduce a human retinal pigmented epithelial (RPE) cell-culture model that mimics
several key aspects of early stage age-related macular degeneration (AMD). These include …