[PDF][PDF] Angiotensin-converting enzyme 2, angiotensin-(1-7) and Mas: new players of the renin-angiotensin system
Abstract Angiotensin (Ang)-(1–7) is now recognized as a biologically active component of
the renin–angiotensin system (RAS). Ang-(1–7) appears to play a central role in the RAS …
the renin–angiotensin system (RAS). Ang-(1–7) appears to play a central role in the RAS …
Channel-like functions of the 18-kDa translocator protein (TSPO): regulation of apoptosis and steroidogenesis as part of the host-defense response
L Veenman, V Papadopoulos… - Current pharmaceutical …, 2007 - ingentaconnect.com
Due to its channel-like properties, the peripheral-type benzodiazepine receptor (PBR) has
been renamed the translocator protein (TSPO). In eukaryotes, the TSPO is primarily located …
been renamed the translocator protein (TSPO). In eukaryotes, the TSPO is primarily located …
[HTML][HTML] Microglial pro-inflammatory and anti-inflammatory phenotypes are modulated by translocator protein activation
E Da Pozzo, C Tremolanti, B Costa… - International journal of …, 2019 - mdpi.com
A key role of the mitochondrial Translocator Protein 18 KDa (TSPO) in neuroinflammation
has been recently proposed. However, little is known about TSPO-activated pathways …
has been recently proposed. However, little is known about TSPO-activated pathways …
Erlotinib induces cell cycle arrest and apoptosis in hepatocellular cancer cells and enhances chemosensitivity towards cytostatics
A Huether, M Höpfner, AP Sutter, D Schuppan… - Journal of …, 2005 - Elsevier
BACKGROUND/AIMS: Hepatocellular carcinoma (HCC) is one of the most common cancer-
related causes of death worldwide. In light of the very poor 5-year-survival new therapeutic …
related causes of death worldwide. In light of the very poor 5-year-survival new therapeutic …
Targeting the epidermal growth factor receptor by gefitinib for treatment of hepatocellular carcinoma
M Höpfner, AP Sutter, A Huether, D Schuppan… - Journal of …, 2004 - Elsevier
BACKGROUND/AIMS: Hepatocellular carcinoma (HCC) is one of the most common cancer-
related causes of death worldwide. Due to very poor 5-year-survival new therapeutic …
related causes of death worldwide. Due to very poor 5-year-survival new therapeutic …
[HTML][HTML] Identification of key genes and pathways in cervical cancer by bioinformatics analysis
X Wu, L Peng, Y Zhang, S Chen, Q Lei… - International journal of …, 2019 - ncbi.nlm.nih.gov
Cervical cancer is a common malignant tumour of the female reproductive system that
seriously threatens the health of women. The aims of this study were to identify key genes …
seriously threatens the health of women. The aims of this study were to identify key genes …
Mitochondriotoxic compounds for cancer therapy
VR Fantin, P Leder - Oncogene, 2006 - nature.com
One of the hallmarks of cancer cells is their increased resistance to apoptosis induction.
Alterations in many apoptosis regulators belonging to the intrinsic pathway confer emerging …
Alterations in many apoptosis regulators belonging to the intrinsic pathway confer emerging …
TSPO: kaleidoscopic 18-kDa amid biochemical pharmacology, control and targeting of mitochondria
J Gatliff, M Campanella - Biochemical Journal, 2016 - portlandpress.com
The 18-kDa translocator protein (TSPO) localizes in the outer mitochondrial membrane
(OMM) of cells and is readily up-regulated under various pathological conditions such as …
(OMM) of cells and is readily up-regulated under various pathological conditions such as …
The peripheral benzodiazepine receptor: a promising therapeutic drug target
S Galiegue, N Tinel, P Casellas - Current medicinal chemistry, 2003 - ingentaconnect.com
The peripheral benzodiazepine receptor (PBR) is a critical component of the mitochondrial
permeability transition pore (MPTP), a multiprotein complex located at the contact site …
permeability transition pore (MPTP), a multiprotein complex located at the contact site …
[HTML][HTML] Translocator protein (TSPO) as a potential biomarker in human cancers
TSPO is a receptor involved in the regulation of cellular proliferation, apoptosis and
mitochondrial functions. Previous studies showed that the expression of TSPO protein …
mitochondrial functions. Previous studies showed that the expression of TSPO protein …