Cell death signaling

DR Green, F Llambi - Cold Spring Harbor perspectives …, 2015 - cshperspectives.cshlp.org
In multicellular organisms, cell death is a critical and active process that maintains tissue
homeostasis and eliminates potentially harmful cells. There are three major types of …

The translational regulation in mTOR pathway

M Yang, Y Lu, W Piao, H Jin - Biomolecules, 2022 - mdpi.com
The mechanistic/mammalian target of rapamycin (mTOR) plays a master role in cell
proliferation and growth in response to insulin, amino acids, energy levels, and oxygen …

[HTML][HTML] The Dystrophin Complex: structure, function and implications for therapy

Q Gao, EM McNally - Comprehensive physiology, 2015 - ncbi.nlm.nih.gov
The dystrophin complex stabilizes the plasma membrane of striated muscle cells. Loss of
function mutations in the genes encoding dystrophin, or the associated proteins, triggers …

[HTML][HTML] Targeting RAS–RAF–MEK–ERK signaling pathway in human cancer: current status in clinical trials

Y Song, Z Bi, Y Liu, F Qin, Y Wei, X Wei - Genes & diseases, 2023 - Elsevier
Molecular target inhibitors have been regularly approved by Food and Drug Administration
(FDA) for tumor treatment, and most of them intervene in tumor cell proliferation and …

Evading apoptosis in cancer

K Fernald, M Kurokawa - Trends in cell biology, 2013 - cell.com
Carcinogenesis is a mechanistically complex and variable process with a plethora of
underlying genetic causes. Cancer development comprises a multitude of steps that occur …

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

MC Mendoza, EE Er, J Blenis - Trends in biochemical sciences, 2011 - cell.com
The Ras-extracellular signal-regulated kinase (Ras-ERK) and phosphatidylinositol 3-kinase-
mammalian target of rapamycin (PI3K-mTOR) signaling pathways are the chief mechanisms …

Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks

B Magnuson, B Ekim, DC Fingar - Biochemical Journal, 2012 - portlandpress.com
The ribosomal protein S6K (S6 kinase) represents an extensively studied effector of the
TORC1 [TOR (target of rapamycin) complex 1], which possesses important yet incompletely …

Mitochondrial membrane permeabilization in cell death

G Kroemer, L Galluzzi, C Brenner - Physiological reviews, 2007 - journals.physiology.org
Irrespective of the morphological features of end-stage cell death (that may be apoptotic,
necrotic, autophagic, or mitotic), mitochondrial membrane permeabilization (MMP) is …

Apoptosis: a link between cancer genetics and chemotherapy

RW Johnstone, AA Ruefli, SW Lowe - Cell, 2002 - cell.com
Defects in apoptosis underpin both tumorigenesis and drug resistance, and because of
these defects chemotherapy often fails. Understanding the molecular events that contribute …

Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury

E Murphy, C Steenbergen - Physiological reviews, 2008 - journals.physiology.org
Mitochondria play an important role in cell death and cardioprotection. During ischemia,
when ATP is progressively depleted, ion pumps cannot function resulting in a rise in calcium …