As brutally demonstrated by the COVID-19 pandemic, an effective immune system is
essential for survival. Developed over evolutionary time, viral nucleic acid detection is a …

Notable advances in gene sequencing methods in recent years have permitted enormous
progress in the phenotypic and genotypic characterization of autoinflammatory syndromes …

A critical step in preserving protein homeostasis is the recognition, binding, unfolding, and
translocation of protein substrates by six AAA-ATPase proteasome subunits (ATPase …

Monogenic autoinflammatory diseases are a group of rheumatologic disorders caused by
dysregulation in the innate immune system. The molecular mechanisms of these disorders …

The majority of critically ill intensive care unit (ICU) patients with severe sepsis develop ICU-
acquired weakness (ICUAW) characterized by loss of muscle mass, reduction in myofiber …

The ubiquitin–proteasome system (UPS) is involved in multiple cellular functions including
the regulation of protein homeostasis, major histocompatibility (MHC) class I antigen …

Abstract Ubiquitin Proteasome System (UPS) is an adaptable and finely tuned system that
sustains proteostasis network under a large variety of physiopathological conditions. Its …

A number of systemic autoinflammatory diseases arise from gain-of-function mutations in
genes encoding IL-1–activating inflammasomes or cytoplasmic nucleic acid sensors …

Mutations in genes coding for proteasome subunits and/or proteasome assembly helpers
typically cause recurring autoinflammation referred to as chronic atypical neutrophilic …

Systemic autoinflammatory diseases are a heterogeneous family of disorders characterized
by a dysregulation of the innate immune system, in which sterile inflammation primarily …